TY - JOUR
T1 - Effects of adrenoceptor agonists and antagonists on sulfobromophthalein disposition in mice
AU - Ben-Zvi, Zvi
AU - Hurwitz, Aryeh
N1 - Funding Information:
This work is supported by Grant KS-85-G-23 from the American Heart Association, Kansas Affiliate.
PY - 1987/6/4
Y1 - 1987/6/4
N2 - The effects of α2-adrenoceptor agonists on sulfobromophthalein (BSP) disposition in mice were studied. It was found that agents with both central and peripheral activities (clonidine, guanabenz, B-HT 920 and methyldopa) as well as peripherally acting α2-adrenoceptor agonists (para amino-clonidine and St 91) inhibited sulfobromophthalein disposition in the mouse, and also caused substantial hypothermia. The effects of these agonists were inhibited by yohimbine, a specific α2-antagonist, except for those of para amino-clonidine where only partial reversal was achieved. The effects of clonidine on BSP disposition were also reversed by piperoxan but not by the α1-adrenoceptor antagonists, prazosin and phenoxybenzamine, nor by the β-blocker, propranolol. These results suggest that, in mice, peripheral α2-adrenoceptors are involved in the effects of the α-agonists on BSP disposition.
AB - The effects of α2-adrenoceptor agonists on sulfobromophthalein (BSP) disposition in mice were studied. It was found that agents with both central and peripheral activities (clonidine, guanabenz, B-HT 920 and methyldopa) as well as peripherally acting α2-adrenoceptor agonists (para amino-clonidine and St 91) inhibited sulfobromophthalein disposition in the mouse, and also caused substantial hypothermia. The effects of these agonists were inhibited by yohimbine, a specific α2-antagonist, except for those of para amino-clonidine where only partial reversal was achieved. The effects of clonidine on BSP disposition were also reversed by piperoxan but not by the α1-adrenoceptor antagonists, prazosin and phenoxybenzamine, nor by the β-blocker, propranolol. These results suggest that, in mice, peripheral α2-adrenoceptors are involved in the effects of the α-agonists on BSP disposition.
KW - Clonidine
KW - Hypothermia
KW - Sulfobromophthalein
KW - α-Adrenoceptor agonists
KW - α-Adrenoceptor antagonists
UR - http://www.scopus.com/inward/record.url?scp=0023229206&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(87)90222-6
DO - 10.1016/0014-2999(87)90222-6
M3 - Article
C2 - 3609141
AN - SCOPUS:0023229206
SN - 0014-2999
VL - 137
SP - 191
EP - 196
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -