Effects of adolescent substance use disorders on central cholinergic function

S. R. Hauser, Z. A. Rodd, G. A. Deehan, T. Liang, Shafiqur Rahman, Richard L. Bell

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Adolescence is a transitional period between childhood and adulthood, in which the individual undergoes significant cognitive, behavioral, physical, emotional, and social developmental changes. During this period, adolescents engage in experimentation and risky behaviors such as licit and illicit drug use. Adolescents' high vulnerability to abuse drugs and natural reinforcers leads to greater risk for developing substance use disorders (SUDs) during adulthood. Accumulating evidence indicates that the use and abuse of licit and illicit drugs during adolescence and emerging adulthood can disrupt the cholinergic system and its processes. This review will focus on the effects of peri-adolescent nicotine and/or alcohol use, or exposure, on the cholinergic system during adulthood from preclinical and clinical studies. This review further explores potential cholinergic agents and pharmacological manipulations to counteract peri-adolescent nicotine and/or alcohol abuse.

Original languageEnglish
Title of host publicationEffects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part I
EditorsRichard L. Bell, Shafiqur Rahman
PublisherAcademic Press Inc.
Number of pages47
ISBN (Print)9780128208052
StatePublished - Jan 2021
Externally publishedYes

Publication series

NameInternational Review of Neurobiology
ISSN (Print)0074-7742
ISSN (Electronic)2162-5514


  • Adolescent
  • Alcohol
  • Animal model
  • Cholinergic system
  • Nicotine


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