Effects of adenosine analogues on guinea-pig endometrial secretion

Margareta Hammarström, N. Peter Wiklund, Ulf E. Samuelson

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1 Scopus citations


The effect of adenosine analogues on guinea-pig endometrial secretion was studied in vitro at defined days of the estrous cycle. The adenosine analogues, 5′-N-ethylcarbox-amideadenosine (NECA) and (N6-[(R)-1-methyl-2-pheny!ethyl]-adenosine (R-PIA), induced endometrial secretion at ovulation time (cycle days 16-1) and at implantation time (cycle days 6-7). The secretory response to NECA was antagonized by 8-p-sulfophenyltheophylline. Scopolamine had no effect on secretion induced by the adenosine analogues. Endometrial secretion induced by field stimulation was inhibited by NECA but not by R-PIA at ovulation time. At implantation time, both NECA and R-PIA reversed the response to field stimulation to values below the basal resting level. The latter effect was antagonized by phentol-amine. These findings suggest that adenosine analogues can induce guinea-pig endometrial secretion by action at stimulatory adenosine receptors, and concomitantly inhibit secreto-motor neurotransmission.

Original languageEnglish
Pages (from-to)224-230
Number of pages7
Issue number4
StatePublished - 1990
Externally publishedYes


  • Adenosine analogues
  • Autonomic nerves
  • Cholinergic innervations
  • Endometrial secretion
  • Uterus


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