@article{4f70dad525bf4985899fe82263ea5950,
title = "Effects of acute endotoxemia and glucose administration on circulating leukocyte populations in normal and diabetic subjects",
abstract = "Effects of intravenous endotoxin and glucose administration on circulating leukocyte populations were compared in seven normal subjects and seven patients with juvenile-onset diabetes by means of automated cytochemical differential counting to quantitate each cell type. Both groups had comparable control cell counts that were unaffected by glucose tolerance testing but altered significantly by endotoxin. Different patterns of response to endotoxin were observed for different circulating cell types. The response of diabetics was parallel to that of normals but showed lower neutrophil and monocyte rebound, longer lasting depression of lymphocytes and eosinophils, and greater rebound of basophils on the day following endotoxin exposure. Characterization of distinctive normal response patterns of circulating leukocyte populations to endotoxin and comparison with responses in diabetics revealed abnormalities under conditions of stress that may impair the diabetic's ability to cope with acute infection.",
author = "Gilbert, {Harriet S.} and Rayfield, {Elliot J.} and Harry Smith and Keusch, {Gerald T.}",
note = "Funding Information: From the Departments of Medicine and Biostatistics, Mourn Sinai School qf Medicine of the CL~L University of New York. New York, N. Y. Supporred in parr by American Cancer Society Grant CH-4OJ. the Jack Marlin Fund, an American Diabetes Association Research and Der{\textquoteright}elopmenr Award, NIH Grant AM 18522. National Insrirure of Child Healrh and Human Developmenl Grani NO I-DH-4-2859. and NIH Grant RR-71. /&I rht, Division of Research Resources, Clinical Research Center. Dr. Rayfield is the recipient of NIH Research Career Development Award K04AM0089. Dr. Keusch is the recipient of Research Career Development Award K04A170847 from the National Institute of Allergy and Infectious Diseases. A preliminary report of this work has been published, in part, in abstract form.{\textquoteright} Received Jbr publication December 21. 1976. Address reprint requests IO Harriet S. Gilbert, M.D., Deparrmenr of Medicine, Mounl Sinai School of Medicine, 19 East 98th SIreel, New York, N. Y. 10029. 0 1978 by Grune & Strarton, Inc. 0026-0495/78/2708~0003$02.00/0",
year = "1978",
month = aug,
doi = "10.1016/0026-0495(78)90132-4",
language = "English",
volume = "27",
pages = "889--899",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "8",
}