Effects of a novel K(ATP) channel blocker on renal tubule function and K channel activity

T. Wang, W. H. Wang, G. Klein-Robbenhaar, G. Giebisch

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

ATP sensitive potassium channels (K(ATP)) modulate Na, K and Cl reabsorption in the thick ascending limb of the loop of Henle and K secretion in the cortical collecting tubule. Inhibition of potassium recycling in the apical membrane of the thick ascending limb of the loop of Henle interferes with sodium reabsorption and suppression of the apical potassium conductance in principal cells of the cortical collecting tubule and reduces potassium secretion. Both potassium recycling and potassium secretion depend critically on the activity of K(ATP), and recent studies indicate that the sulfonylurea compound glyburide, a known K(ATP) channel blocker, is diuretic but does not produce kaliuresis.

Original languageEnglish
Pages (from-to)1382-1389
Number of pages8
JournalJournal of Pharmacology and Experimental Therapeutics
Volume273
Issue number3
StatePublished - 1995
Externally publishedYes

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