Abstract
Zinc is an essential micronutrient for all living cells. It serves as a structural and catalytic cofactor for numerous proteins, hence maintaining a proper level of cellular zinc is essential for normal functioning of the cell. Zinc homeostasis is sustained through various ways under severe zinc-deficient conditions. Zinc-dependent proteins play an important role in biological systems and limitation of zinc causes a drastic change in their expression. In budding yeast, a zinc-responsive transcription factor Zap1p controls the expression of genes required for uptake and mobilization of zinc under zinc-limiting conditions. It also regulates the polar lipid levels under zinc-limiting conditions to maintain membrane integrity. Deletion of ZAP1 causes an increase in triacylglyerol levels which is due to the increased biosynthesis of acetate that serves as a precursor for triacylglycerol biosynthesis. In this review, we expanded our recent work role of Zap1p in nonpolar lipid metabolism of budding yeast.
| Original language | English |
|---|---|
| Pages (from-to) | 977-982 |
| Number of pages | 6 |
| Journal | Current Genetics |
| Volume | 63 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1 Dec 2017 |
| Externally published | Yes |
Keywords
- Micronutrients
- Nonpolar lipids
- Polar lipids
- Zinc homeostasis
- Zinc limitation