Effect of zinc deprivation on the lipid metabolism of budding yeast

Neelima Singh, Kamlesh Kumar Yadav, Ram Rajasekharan

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Zinc is an essential micronutrient for all living cells. It serves as a structural and catalytic cofactor for numerous proteins, hence maintaining a proper level of cellular zinc is essential for normal functioning of the cell. Zinc homeostasis is sustained through various ways under severe zinc-deficient conditions. Zinc-dependent proteins play an important role in biological systems and limitation of zinc causes a drastic change in their expression. In budding yeast, a zinc-responsive transcription factor Zap1p controls the expression of genes required for uptake and mobilization of zinc under zinc-limiting conditions. It also regulates the polar lipid levels under zinc-limiting conditions to maintain membrane integrity. Deletion of ZAP1 causes an increase in triacylglyerol levels which is due to the increased biosynthesis of acetate that serves as a precursor for triacylglycerol biosynthesis. In this review, we expanded our recent work role of Zap1p in nonpolar lipid metabolism of budding yeast.

Original languageEnglish
Pages (from-to)977-982
Number of pages6
JournalCurrent Genetics
Issue number6
StatePublished - 1 Dec 2017
Externally publishedYes


  • Micronutrients
  • Nonpolar lipids
  • Polar lipids
  • Zinc homeostasis
  • Zinc limitation


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