Effect of tumor promoters on human T cell leukemia/lymphoma virus (HTLV)-structural protein induction in adult T-cell leukemia cells

Yoshinobu Nakao; Shuichi Matsuda; Toshimitsu Matsui; Toshitaro Nakagawa; Takuo Fujita; Takashi Uchiyama; Sakan Maeda; Yuruko Okamoto; Tohru Masaoka; Yohei Ito

doi:10.1016/0304-3835(84)90128-9

Effect of tumor promoters on human T cell leukemia/lymphoma virus (HTLV)-structural protein induction in adult T-cell leukemia cells

Yoshinobu Nakao
, Shuichi Matsuda
, Toshimitsu Matsui
, Toshitaro Nakagawa
, Takuo Fujita
, Takashi Uchiyama
, Sakan Maeda
, Yuruko Okamoto
, Tohru Masaoka
, Yohei Ito

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We assayed the capacity of tumor promoters to induce human T-cell leukemia/lymphoma virus (HTLV) structural proteins p19 and p24 from the HTLV genome-carrying adult T-cell leukemia (ATL) cell lines, MT-1 and KH-2lo, and fresh ATL cells. Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24. This suggests that certain environmental substances, especially those known to be tumor promoters, may activate the HTLV-gene in ATL cells.

Original language	English
Pages (from-to)	129-139
Number of pages	11
Journal	Cancer Letters
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(84)90128-9
State	Published - Sep 1984
Externally published	Yes

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@article{04656b00e69c4efa8a6aacbe85a43b2e,

title = "Effect of tumor promoters on human T cell leukemia/lymphoma virus (HTLV)-structural protein induction in adult T-cell leukemia cells",

abstract = "We assayed the capacity of tumor promoters to induce human T-cell leukemia/lymphoma virus (HTLV) structural proteins p19 and p24 from the HTLV genome-carrying adult T-cell leukemia (ATL) cell lines, MT-1 and KH-2lo, and fresh ATL cells. Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24. This suggests that certain environmental substances, especially those known to be tumor promoters, may activate the HTLV-gene in ATL cells.",

author = "Yoshinobu Nakao and Shuichi Matsuda and Toshimitsu Matsui and Toshitaro Nakagawa and Takuo Fujita and Takashi Uchiyama and Sakan Maeda and Yuruko Okamoto and Tohru Masaoka and Yohei Ito",

note = "Funding Information: We are most grateful to Dr. Robert C. Gallo (National Cancer Institute, NIH, Bethesda, MD) for generously providing anti-ATLV p19 and p24 antibodies. We also thank Dr. I. Miyoshi (Department of Medicine, Kochi Medical College, Nangokucity, Japan) for providing MT-1 cells and Mr. D. Mrozek for his critical reading of the manuscript. This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture of Japan and a grant from the Hyogo Prefectural Cancer Society.",

year = "1984",

month = sep,

doi = "10.1016/0304-3835(84)90128-9",

language = "English",

volume = "24",

pages = "129--139",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Effect of tumor promoters on human T cell leukemia/lymphoma virus (HTLV)-structural protein induction in adult T-cell leukemia cells

AU - Nakao, Yoshinobu

AU - Matsuda, Shuichi

AU - Matsui, Toshimitsu

AU - Nakagawa, Toshitaro

AU - Fujita, Takuo

AU - Uchiyama, Takashi

AU - Maeda, Sakan

AU - Okamoto, Yuruko

AU - Masaoka, Tohru

AU - Ito, Yohei

N1 - Funding Information: We are most grateful to Dr. Robert C. Gallo (National Cancer Institute, NIH, Bethesda, MD) for generously providing anti-ATLV p19 and p24 antibodies. We also thank Dr. I. Miyoshi (Department of Medicine, Kochi Medical College, Nangokucity, Japan) for providing MT-1 cells and Mr. D. Mrozek for his critical reading of the manuscript. This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture of Japan and a grant from the Hyogo Prefectural Cancer Society.

PY - 1984/9

Y1 - 1984/9

N2 - We assayed the capacity of tumor promoters to induce human T-cell leukemia/lymphoma virus (HTLV) structural proteins p19 and p24 from the HTLV genome-carrying adult T-cell leukemia (ATL) cell lines, MT-1 and KH-2lo, and fresh ATL cells. Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24. This suggests that certain environmental substances, especially those known to be tumor promoters, may activate the HTLV-gene in ATL cells.

AB - We assayed the capacity of tumor promoters to induce human T-cell leukemia/lymphoma virus (HTLV) structural proteins p19 and p24 from the HTLV genome-carrying adult T-cell leukemia (ATL) cell lines, MT-1 and KH-2lo, and fresh ATL cells. Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24. This suggests that certain environmental substances, especially those known to be tumor promoters, may activate the HTLV-gene in ATL cells.

UR - https://www.scopus.com/pages/publications/0021634095

U2 - 10.1016/0304-3835(84)90128-9

DO - 10.1016/0304-3835(84)90128-9

M3 - Article

C2 - 6090008

AN - SCOPUS:0021634095

SN - 0304-3835

VL - 24

SP - 129

EP - 139

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Effect of tumor promoters on human T cell leukemia/lymphoma virus (HTLV)-structural protein induction in adult T-cell leukemia cells

Abstract

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