Effect of tumor promoters on human T cell leukemia/lymphoma virus (HTLV)-structural protein induction in adult T-cell leukemia cells

Yoshinobu Nakao, Shuichi Matsuda, Toshimitsu Matsui, Toshitaro Nakagawa, Takuo Fujita, Takashi Uchiyama, Sakan Maeda, Yuruko Okamoto, Tohru Masaoka, Yohei Ito

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We assayed the capacity of tumor promoters to induce human T-cell leukemia/lymphoma virus (HTLV) structural proteins p19 and p24 from the HTLV genome-carrying adult T-cell leukemia (ATL) cell lines, MT-1 and KH-2lo, and fresh ATL cells. Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24. This suggests that certain environmental substances, especially those known to be tumor promoters, may activate the HTLV-gene in ATL cells.

Original languageEnglish
Pages (from-to)129-139
Number of pages11
JournalCancer Letters
Volume24
Issue number2
DOIs
StatePublished - Sep 1984
Externally publishedYes

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