Effect of subzero-balanced ultrafiltration on lung gas exchange capacity after cardiopulmonary bypass in adult patients with heart valve disease

Tao Zhang, Sheng Li Jiang, Chang Qing Gao, Jin Luo, Lan Ma, Jia Chun Li

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objectives: This study was conducted to evaluate the effect of a new ultrafiltration technique - the subzero-balanced ultrafiltration (SBUF) - on lung gas exchange capacity after cardiopulmonary bypass (CPB) in adult patients with heart valve disease. Background: Attenuation of lung gas exchange capacity is one of the most common manifestations of an inflammatory response after CPB. Methods: Ninety-four patients who required CPB for cardiac surgery were randomized into 2 groups according to whether they received SBUF. Gas exchange capacity expressed as the oxygen index (OI), the respiratory index (RI), and the alveolar-arterial oxygen pressure difference (P(A-a)O2) were measured after intubation (T1), at the termination of CPB (T2), on admission to the intensive care unit (ICU) (T3), at postoperative hour 6 (T4), and at postoperative hour 12 (T 5). Results: There were no significant differences in gas exchange capacity between the 2 groups at T1, T4, and T 5. CPB produced significant changes in OI, RI, and P (A-a)O2 in the control group, whereas these changes were not significantly different in the study group. The OI in the study group was significantly higher at T2, and RI and P(A-a)O2 were significantly lower at T2 and T3. In the study group, the intubation time was shorter, and the transfusion volume within 24 hours postoperatively was less. The 2 groups were comparable with respect to the incidence of respiratory complications, length of stay in the ICU, duration of hospital stay, need for infusions of inotropic agents, and drainage volumes within 24 hours postoperatively. Conclusions: SBUF during CPB can produce an immediate improvement in lung gas exchange capacity, which may effectively minimize pulmonary dysfunction in adult patients undergoing cardiac surgery.

Original languageEnglish
Pages (from-to)E22-E27
JournalHeart Surgery Forum
Volume14
Issue number1
DOIs
StatePublished - Feb 2011
Externally publishedYes

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