Effect of SPP 635, a renin inhibitor, on intraocular pressure in glaucomatous monkey eyes

Rong Fang Wang, Steven M. Podos, Janet B. Serle, Ovidiu C. Baltatu

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The effect of topical application of SPP 635, a renin inhibitor, on intraocular pressure (IOP) was evaluated in the eyes of monkeys with laser induced unilateral glaucoma. A multiple-dose study was performed in 8 glaucomatous monkey eyes with 3 concentrations of SPP 635, 0.2%, 0.3% and 0.4%. IOP was measured hourly for 6h on each day of the study beginning at 9:30 a.m. Following one baseline day (untreated) and one vehicle-treated day (50μl drop of vehicle to the glaucomatous eye at 9:30 a.m.), a 50μl drop (25μl×2) of SPP 635, 0.2%, 0.3% or 0.4%, was topically applied to the glaucomatous eye at 9:30 a.m. and 3:30 p.m. for 5 consecutive days. Twice daily administration of each of the 3 concentrations of SPP 635 for 5 days significantly (p<0.05) reduced IOP. The maximum reduction in IOP occurred 3 or 4h after morning dosing and was 4.3±0.8 (mean±SEM) mmHg (14%) for 0.2% SPP 635, 5.3±1.0mmHg, (19%) for 0.3% SPP 635, and 8.0±1.3mmHg (25%) for 0.4% SPP 635. The longest duration of IOP reduction was for 6h with 0.2% or 0.3% SPP 635, and was for at least 18h with 0.4% concentration. Compared to 0.2% or 0.3% concentrations, 0.4% SPP 635 produced a greater (p<0.05) and longer duration of IOP reduction (18 vs. 6h). Mild conjunctival discharge appeared in 2 of 8 eyes, and hyperemia appeared in 2 eyes with the 0.3% and 0.4% concentrations on treatment days 3 and 5. Topically applied SPP 635, a new renin inhibitor, reduces IOP in glaucomatous monkeys in a dose-dependent manner. Renin inhibitors, are a novel class of compounds which may have potential for the treatment of glaucoma.

Original languageEnglish
Pages (from-to)146-149
Number of pages4
JournalExperimental Eye Research
Volume94
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Glaucoma monkey
  • Intraocular pressure
  • Renin inhibitor
  • Renin-angiotensin system
  • SPP 635

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