TY - JOUR
T1 - Effect of prostaglandin F(2α) on aqueous humor dynamics of rabbit, cat, and monkey
AU - Lee, P.
AU - Podos, S. M.
AU - Severin, C.
PY - 1984
Y1 - 1984
N2 - Topical administration of prostaglandin F(2α) [PGF(2α)] produced a reduction in intraocular pressure in eyes of rabbits, cats, and cynomolgus monkeys. In rabbit eyes at 5 or 6 hr, 50 μg, 100 μg, or 250 μg of PGS(2α), caused a significant intraocular pressure reduction with a small miotic effect. Treatment with 500 μg, 750 μg, or 1000 μg of PGF(2α), lowered intraocular pressure significantly in cat eyes for at least 24 hr with the development of profound pupillary constriction. Administration of 500 μg, 750 μg, or 1000 μg of PGF(2α), produced a significant reduction of intraocular pressure in monkey eyes lasting at least 24 hr, with an initial hypertensive phase and a small decrease in pupillary diameter in the treated eyes. Tonography revealed an increased facility of outflow simultaneous with the reduction of intraocular pressure in the eyes of cats and monkeys. These increases of outflow facility could not explain completely the reductions in intraocular pressure. The aqueous humor flow measured by fluorophotometry was unaltered in both species, and possible reasons for this finding are discussed. Anterior chamber aqueous humor protein was significantly higher in cat eyes topically treated with 750 μg of PGF(2α) than in the diluent-treated fellow eyes.
AB - Topical administration of prostaglandin F(2α) [PGF(2α)] produced a reduction in intraocular pressure in eyes of rabbits, cats, and cynomolgus monkeys. In rabbit eyes at 5 or 6 hr, 50 μg, 100 μg, or 250 μg of PGS(2α), caused a significant intraocular pressure reduction with a small miotic effect. Treatment with 500 μg, 750 μg, or 1000 μg of PGF(2α), lowered intraocular pressure significantly in cat eyes for at least 24 hr with the development of profound pupillary constriction. Administration of 500 μg, 750 μg, or 1000 μg of PGF(2α), produced a significant reduction of intraocular pressure in monkey eyes lasting at least 24 hr, with an initial hypertensive phase and a small decrease in pupillary diameter in the treated eyes. Tonography revealed an increased facility of outflow simultaneous with the reduction of intraocular pressure in the eyes of cats and monkeys. These increases of outflow facility could not explain completely the reductions in intraocular pressure. The aqueous humor flow measured by fluorophotometry was unaltered in both species, and possible reasons for this finding are discussed. Anterior chamber aqueous humor protein was significantly higher in cat eyes topically treated with 750 μg of PGF(2α) than in the diluent-treated fellow eyes.
UR - http://www.scopus.com/inward/record.url?scp=0021285372&partnerID=8YFLogxK
M3 - Article
C2 - 6590527
AN - SCOPUS:0021285372
SN - 0146-0404
VL - 25
SP - 1087
EP - 1093
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 9
ER -