Effect of prostaglandin F(2α) on aqueous humor dynamics of rabbit, cat, and monkey

P. Lee, S. M. Podos, C. Severin

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

Topical administration of prostaglandin F(2α) [PGF(2α)] produced a reduction in intraocular pressure in eyes of rabbits, cats, and cynomolgus monkeys. In rabbit eyes at 5 or 6 hr, 50 μg, 100 μg, or 250 μg of PGS(2α), caused a significant intraocular pressure reduction with a small miotic effect. Treatment with 500 μg, 750 μg, or 1000 μg of PGF(2α), lowered intraocular pressure significantly in cat eyes for at least 24 hr with the development of profound pupillary constriction. Administration of 500 μg, 750 μg, or 1000 μg of PGF(2α), produced a significant reduction of intraocular pressure in monkey eyes lasting at least 24 hr, with an initial hypertensive phase and a small decrease in pupillary diameter in the treated eyes. Tonography revealed an increased facility of outflow simultaneous with the reduction of intraocular pressure in the eyes of cats and monkeys. These increases of outflow facility could not explain completely the reductions in intraocular pressure. The aqueous humor flow measured by fluorophotometry was unaltered in both species, and possible reasons for this finding are discussed. Anterior chamber aqueous humor protein was significantly higher in cat eyes topically treated with 750 μg of PGF(2α) than in the diluent-treated fellow eyes.

Original languageEnglish
Pages (from-to)1087-1093
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume25
Issue number9
StatePublished - 1984

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