Effect of phosphodiesterase inhibitors in the bladder

Bilal Chughtai; Aizaz Ali; Claire Dunphy; Steven A. Kaplan

doi:10.1016/j.ajur.2015.04.014

Effect of phosphodiesterase inhibitors in the bladder

Bilal Chughtai, Aizaz Ali, Claire Dunphy, Steven A. Kaplan

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, Kchannel modulated pathways, and the L-cysteine/H2S pathway. PDE5 inhibitors exert their effect in muscle cells, nerve fibers, and interstitial cells (ICs). The use of PDE5 inhibitors led to improvement in LUTS. This included urodynamic parameters. PDE5 inhibitors may play a significant role in LUTS due to their effect on the bladder rather than the prostate.

Original language	English
Pages (from-to)	33-37
Number of pages	5
Journal	Asian Journal of Urology
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/j.ajur.2015.04.014
State	Published - 6 Feb 2015
Externally published	Yes

Keywords

Lower urinary tract symptoms (LUTS)
NO/cGMP
Overactive bladder syndrome (OAB)
Phosphodiesterase type 5 inhibitors
cAMP

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10.1016/j.ajur.2015.04.014

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title = "Effect of phosphodiesterase inhibitors in the bladder",

abstract = "Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, Kchannel modulated pathways, and the L-cysteine/H2S pathway. PDE5 inhibitors exert their effect in muscle cells, nerve fibers, and interstitial cells (ICs). The use of PDE5 inhibitors led to improvement in LUTS. This included urodynamic parameters. PDE5 inhibitors may play a significant role in LUTS due to their effect on the bladder rather than the prostate.",

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T1 - Effect of phosphodiesterase inhibitors in the bladder

AU - Chughtai, Bilal

AU - Ali, Aizaz

AU - Dunphy, Claire

AU - Kaplan, Steven A.

PY - 2015/2/6

Y1 - 2015/2/6

N2 - Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, Kchannel modulated pathways, and the L-cysteine/H2S pathway. PDE5 inhibitors exert their effect in muscle cells, nerve fibers, and interstitial cells (ICs). The use of PDE5 inhibitors led to improvement in LUTS. This included urodynamic parameters. PDE5 inhibitors may play a significant role in LUTS due to their effect on the bladder rather than the prostate.

AB - Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, Kchannel modulated pathways, and the L-cysteine/H2S pathway. PDE5 inhibitors exert their effect in muscle cells, nerve fibers, and interstitial cells (ICs). The use of PDE5 inhibitors led to improvement in LUTS. This included urodynamic parameters. PDE5 inhibitors may play a significant role in LUTS due to their effect on the bladder rather than the prostate.

KW - Lower urinary tract symptoms (LUTS)

KW - NO/cGMP

KW - Overactive bladder syndrome (OAB)

KW - Phosphodiesterase type 5 inhibitors

KW - cAMP

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DO - 10.1016/j.ajur.2015.04.014

M3 - Review article

AN - SCOPUS:85027856046

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VL - 2

SP - 33

EP - 37

JO - Asian Journal of Urology

JF - Asian Journal of Urology

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Effect of phosphodiesterase inhibitors in the bladder

Abstract

Keywords

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