Effect of Parenteral Acetazolamide on Intestinal Absorption of Salt and Water in Man

Charles D. Gerson, Nathaniel Cohen, Martin Finkel, Henry D. Janowitz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Acetazolamide was administered intravenously during jejunal perfusion of isotonic saline in six subjects. Bicarbonate was present in very low concentration intraluminally and there was net bicarbonate secretion during control and acetazolamide perfusions. Acetazolamide significantly inhibited sodium chloride, and water absorption. As this occurred in the absence of an effect on net bicarbonate secretion, it may have been due to an action other than carbonic anhydrase inhibition. This research was supported by the National Foundation for Ileitis and Colitis, Inc., and by Grant RR-71 to the Clinical Research Center of The Mount Sinai Hospital. Lederle Laboratories kindly donated the acetazolamide.

Original languageEnglish
Pages (from-to)950-952
Number of pages3
JournalExperimental Biology and Medicine
Volume149
Issue number4
DOIs
StatePublished - 8 Sep 1975
Externally publishedYes

Fingerprint

Dive into the research topics of 'Effect of Parenteral Acetazolamide on Intestinal Absorption of Salt and Water in Man'. Together they form a unique fingerprint.

Cite this