Effect of obesity on clinical presentation and response to treatment in asthma

Anne E. Dixon; David M. Shade; Rubin I. Cohen; Gwen S. Skloot; Janet T. Holbrook; Lewis J. Smith; John J. Lima; Hooman Allayee; Charles G. Irvin; Robert A. Wise

doi:10.1080/02770900600859123

Effect of obesity on clinical presentation and response to treatment in asthma

Anne E. Dixon, David M. Shade, Rubin I. Cohen, Gwen S. Skloot, Janet T. Holbrook, Lewis J. Smith, John J. Lima, Hooman Allayee, Charles G. Irvin, Robert A. Wise

Research output: Contribution to journal › Article › peer-review

127 Scopus citations

Abstract

Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.

Original language	English
Pages (from-to)	553-558
Number of pages	6
Journal	Journal of Asthma
Volume	43
Issue number	7
DOIs	https://doi.org/10.1080/02770900600859123
State	Published - 1 Aug 2006
Externally published	Yes

Keywords

Asthma
Gastroesophageal reflux disease
Obesity
Spirometry
Theophylline

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10.1080/02770900600859123

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title = "Effect of obesity on clinical presentation and response to treatment in asthma",

abstract = "Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.",

keywords = "Asthma, Gastroesophageal reflux disease, Obesity, Spirometry, Theophylline",

author = "Dixon, {Anne E.} and Shade, {David M.} and Cohen, {Rubin I.} and Skloot, {Gwen S.} and Holbrook, {Janet T.} and Smith, {Lewis J.} and Lima, {John J.} and Hooman Allayee and Irvin, {Charles G.} and Wise, {Robert A.}",

note = "Funding Information: Supported by the American Lung Association and grant K23 RR019965. ∗Corresponding author: Anne E. Dixon, M.D., Pulmonary and Critical Care Medicine, Patrick 204, Fletcher Allen Health Care, 111 Colchester Avenue, Burlington, VT 05401; E-mail: [email protected]",

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doi = "10.1080/02770900600859123",

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T1 - Effect of obesity on clinical presentation and response to treatment in asthma

AU - Dixon, Anne E.

AU - Shade, David M.

AU - Cohen, Rubin I.

AU - Skloot, Gwen S.

AU - Holbrook, Janet T.

AU - Smith, Lewis J.

AU - Lima, John J.

AU - Allayee, Hooman

AU - Irvin, Charles G.

AU - Wise, Robert A.

N1 - Funding Information: Supported by the American Lung Association and grant K23 RR019965. ∗Corresponding author: Anne E. Dixon, M.D., Pulmonary and Critical Care Medicine, Patrick 204, Fletcher Allen Health Care, 111 Colchester Avenue, Burlington, VT 05401; E-mail: [email protected]

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.

AB - Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.

KW - Asthma

KW - Gastroesophageal reflux disease

KW - Obesity

KW - Spirometry

KW - Theophylline

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JO - Journal of Asthma

JF - Journal of Asthma

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ER -

Effect of obesity on clinical presentation and response to treatment in asthma

Abstract

Keywords

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