Effect of n-butyrate on cellular and viral DNA synthesis in cells latently infected with Epstein-Barr virus

Ari K. Saemundsen, Bengt Kallin, George Klein

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Cellular DNA synthesis and Epstein-Barr virus (EBV)-specific DNA synthesis was examined after n-butyrate treatment of the producer line P3HR-1. Butyrate was found to effectively inhibit cellular DNA synthesis. This was followed by activation of the viral cycle as seen by marked increase in the expression of the EBV early antigen (EA), viral capsid antigen, and EBV-specific DNA synthesis. In spite of efficient induction of EA in the nonproducer Raji line, there was no increase in EBV-specific DNA synthesis above the level of the untreated control. It is likely that the cellular inhibitory effects of n-butyrate are responsible for the activation of EBV in producer lines and that different cellular controls, not affected by n-butyrate, are responsible for keeping the virus latent in nonproducer cells.

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalVirology
Volume107
Issue number2
DOIs
StatePublished - Dec 1980
Externally publishedYes

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