Abstract
Cellular DNA synthesis and Epstein-Barr virus (EBV)-specific DNA synthesis was examined after n-butyrate treatment of the producer line P3HR-1. Butyrate was found to effectively inhibit cellular DNA synthesis. This was followed by activation of the viral cycle as seen by marked increase in the expression of the EBV early antigen (EA), viral capsid antigen, and EBV-specific DNA synthesis. In spite of efficient induction of EA in the nonproducer Raji line, there was no increase in EBV-specific DNA synthesis above the level of the untreated control. It is likely that the cellular inhibitory effects of n-butyrate are responsible for the activation of EBV in producer lines and that different cellular controls, not affected by n-butyrate, are responsible for keeping the virus latent in nonproducer cells.
Original language | English |
---|---|
Pages (from-to) | 557-561 |
Number of pages | 5 |
Journal | Virology |
Volume | 107 |
Issue number | 2 |
DOIs | |
State | Published - Dec 1980 |
Externally published | Yes |