Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia

B. Eggleston; M. Patience; S. Edwards; T. Adamkiewicz; G. R. Buchanan; S. C. Davies; R. Dickerhoff; S. Donfield; S. A. Feig; R. H. Giller; A. Haight; J. Horan; L. L. Hsu; N. Kamani; P. Lane; J. E. Levine; D. Margolis; T. B. Moore; K. Ohene-Frempong; R. Redding-Lallinger; I. A.G. Roberts; Z. R. Rogers; J. E. Sanders; J. P. Scott; B. Sleight; A. A. Thompson; K. M. Sullivan; M. C. Walters

doi:10.1111/j.1365-2141.2006.06486.x

Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia

B. Eggleston, M. Patience, S. Edwards, T. Adamkiewicz, G. R. Buchanan, S. C. Davies, R. Dickerhoff, S. Donfield, S. A. Feig, R. H. Giller, A. Haight, J. Horan, L. L. Hsu, N. Kamani, P. Lane, J. E. Levine, D. Margolis, T. B. Moore, K. Ohene-Frempong, R. Redding-LallingerI. A.G. Roberts, Z. R. Rogers, J. E. Sanders, J. P. Scott, B. Sleight, A. A. Thompson, K. M. Sullivan, M. C. Walters

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43 Scopus citations

Abstract

Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.

Original language	English
Pages (from-to)	673-676
Number of pages	4
Journal	British Journal of Haematology
Volume	136
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.2006.06486.x
State	Published - Feb 2007
Externally published	Yes

Keywords

Sickle cell anaemia
Transplantation

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10.1111/j.1365-2141.2006.06486.x

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Eggleston, B., Patience, M., Edwards, S., Adamkiewicz, T., Buchanan, G. R., Davies, S. C., Dickerhoff, R., Donfield, S., Feig, S. A., Giller, R. H., Haight, A., Horan, J., Hsu, L. L., Kamani, N., Lane, P., Levine, J. E., Margolis, D., Moore, T. B., Ohene-Frempong, K., ... Walters, M. C. (2007). Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. British Journal of Haematology, 136(4), 673-676. https://doi.org/10.1111/j.1365-2141.2006.06486.x

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title = "Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia",

abstract = "Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.",

keywords = "Sickle cell anaemia, Transplantation",

author = "B. Eggleston and M. Patience and S. Edwards and T. Adamkiewicz and Buchanan, {G. R.} and Davies, {S. C.} and R. Dickerhoff and S. Donfield and Feig, {S. A.} and Giller, {R. H.} and A. Haight and J. Horan and Hsu, {L. L.} and N. Kamani and P. Lane and Levine, {J. E.} and D. Margolis and Moore, {T. B.} and K. Ohene-Frempong and R. Redding-Lallinger and Roberts, {I. A.G.} and Rogers, {Z. R.} and Sanders, {J. E.} and Scott, {J. P.} and B. Sleight and Thompson, {A. A.} and Sullivan, {K. M.} and Walters, {M. C.}",

year = "2007",

month = feb,

doi = "10.1111/j.1365-2141.2006.06486.x",

language = "English",

volume = "136",

pages = "673--676",

journal = "British Journal of Haematology",

issn = "0007-1048",

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Eggleston, B, Patience, M, Edwards, S, Adamkiewicz, T, Buchanan, GR, Davies, SC, Dickerhoff, R, Donfield, S, Feig, SA, Giller, RH, Haight, A, Horan, J, Hsu, LL, Kamani, N, Lane, P, Levine, JE, Margolis, D, Moore, TB, Ohene-Frempong, K, Redding-Lallinger, R, Roberts, IAG, Rogers, ZR, Sanders, JE, Scott, JP, Sleight, B, Thompson, AA, Sullivan, KM & Walters, MC 2007, 'Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia', British Journal of Haematology, vol. 136, no. 4, pp. 673-676. https://doi.org/10.1111/j.1365-2141.2006.06486.x

Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. / Eggleston, B.; Patience, M.; Edwards, S. et al.
In: British Journal of Haematology, Vol. 136, No. 4, 02.2007, p. 673-676.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia

T2 - Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia

AU - Eggleston, B.

AU - Patience, M.

AU - Edwards, S.

AU - Adamkiewicz, T.

AU - Buchanan, G. R.

AU - Davies, S. C.

AU - Dickerhoff, R.

AU - Donfield, S.

AU - Feig, S. A.

AU - Giller, R. H.

AU - Haight, A.

AU - Horan, J.

AU - Hsu, L. L.

AU - Kamani, N.

AU - Lane, P.

AU - Levine, J. E.

AU - Margolis, D.

AU - Moore, T. B.

AU - Ohene-Frempong, K.

AU - Redding-Lallinger, R.

AU - Roberts, I. A.G.

AU - Rogers, Z. R.

AU - Sanders, J. E.

AU - Scott, J. P.

AU - Sleight, B.

AU - Thompson, A. A.

AU - Sullivan, K. M.

AU - Walters, M. C.

PY - 2007/2

Y1 - 2007/2

N2 - Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.

AB - Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.

KW - Sickle cell anaemia

KW - Transplantation

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DO - 10.1111/j.1365-2141.2006.06486.x

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C2 - 17223910

AN - SCOPUS:33846438578

SN - 0007-1048

VL - 136

SP - 673

EP - 676

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Eggleston B, Patience M, Edwards S, Adamkiewicz T, Buchanan GR, Davies SC et al. Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. British Journal of Haematology. 2007 Feb;136(4):673-676. doi: 10.1111/j.1365-2141.2006.06486.x

Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia

Abstract

Keywords

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