Effect of levo-acetylcarnitine on P300-like potentials of the normal monkey

M. Onofrj, M. F. Ghilardi, A. Faricelli, I. Bodis-Wollner, M. Calvani

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Endogenous components of evoked potentials resembling Psub 3sub 0sub 0 in human beings were sequentially studied in four cynomolgus monkeys (Macaca fascicularis using an auditory 'oddball' paradigm, after classical conditioning training. When robust Psub 3sub 0sub 0-like signals were obtained, each animal underwent further recording sessions in which a placebo, L-carnitine or L-acetylcarnitine (LAC) was injected. Only LAC induced an amplitude increment of Psub 3sub 0sub 0 waves in all the animals and a latency decrement in two animals. Furthermore a transient effect with amplitude reduction on the primary cortical auditory evoked potentials (AEP) both to rare and frequent tones was also recorded in all the animals. This effect resembled the AEP amplitude reduction induced by physostigmine administration. The findings suggest an effect of LAC on normal processes accompanying cognition.

Original languageEnglish
Pages (from-to)407-415
Number of pages9
JournalDrugs under Experimental and Clinical Research
Issue number7
StatePublished - 1987


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