Effect of kainate on ATP levels and glutamate metabolism in cerebellar slices

William J. Nicklas; Barbara Krespan; Soll Berl

doi:10.1016/0014-2999(80)90278-2

Effect of kainate on ATP levels and glutamate metabolism in cerebellar slices

William J. Nicklas
, Barbara Krespan
, Soll Berl

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The levels of ATo and amino acids were measured in rat cerebellar slices incubated in the presence of the neurotoxin, kainic acid (KA). 0.1-1 mM KA caused a significant decrease in tissue content of ATP, glutamate, aspartate and glutamine. The levels of glutamate and aspartat, but not glutamine, rose concomitanly in the incubation medium. The results are consistent with a multiaction mechanism for the neurotoxicity of KA.

Original language	English
Pages (from-to)	209-213
Number of pages	5
Journal	European Journal of Pharmacology
Volume	62
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(80)90278-2
State	Published - 21 Mar 1980

Keywords

ATP
Cerebellum
Glutamic acid
Glutamine
Kainic acid

Access to Document

10.1016/0014-2999(80)90278-2

Cite this

@article{3b269b249f5944719fcd82d7ce91a515,

title = "Effect of kainate on ATP levels and glutamate metabolism in cerebellar slices",

abstract = "The levels of ATo and amino acids were measured in rat cerebellar slices incubated in the presence of the neurotoxin, kainic acid (KA). 0.1-1 mM KA caused a significant decrease in tissue content of ATP, glutamate, aspartate and glutamine. The levels of glutamate and aspartat, but not glutamine, rose concomitanly in the incubation medium. The results are consistent with a multiaction mechanism for the neurotoxicity of KA.",

keywords = "ATP, Cerebellum, Glutamic acid, Glutamine, Kainic acid",

author = "Nicklas, \{William J.\} and Barbara Krespan and Soll Berl",

note = "Funding Information: The authors wish to thank Mrs. Ruth Nicklas for her technical assistance in the amino acid analyses. The dihydrokainic acid and N-methylaspartic acid were kindly provided by Dr. Graham Johnston of the Australian National University, to whom we are most grateful. This work was supported by U.S.P.H.S. grants 25505 and NS 11631.",

year = "1980",

month = mar,

day = "21",

doi = "10.1016/0014-2999(80)90278-2",

language = "English",

volume = "62",

pages = "209--213",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "2-3",

}

TY - JOUR

T1 - Effect of kainate on ATP levels and glutamate metabolism in cerebellar slices

AU - Nicklas, William J.

AU - Krespan, Barbara

AU - Berl, Soll

N1 - Funding Information: The authors wish to thank Mrs. Ruth Nicklas for her technical assistance in the amino acid analyses. The dihydrokainic acid and N-methylaspartic acid were kindly provided by Dr. Graham Johnston of the Australian National University, to whom we are most grateful. This work was supported by U.S.P.H.S. grants 25505 and NS 11631.

PY - 1980/3/21

Y1 - 1980/3/21

N2 - The levels of ATo and amino acids were measured in rat cerebellar slices incubated in the presence of the neurotoxin, kainic acid (KA). 0.1-1 mM KA caused a significant decrease in tissue content of ATP, glutamate, aspartate and glutamine. The levels of glutamate and aspartat, but not glutamine, rose concomitanly in the incubation medium. The results are consistent with a multiaction mechanism for the neurotoxicity of KA.

AB - The levels of ATo and amino acids were measured in rat cerebellar slices incubated in the presence of the neurotoxin, kainic acid (KA). 0.1-1 mM KA caused a significant decrease in tissue content of ATP, glutamate, aspartate and glutamine. The levels of glutamate and aspartat, but not glutamine, rose concomitanly in the incubation medium. The results are consistent with a multiaction mechanism for the neurotoxicity of KA.

KW - ATP

KW - Cerebellum

KW - Glutamic acid

KW - Glutamine

KW - Kainic acid

UR - https://www.scopus.com/pages/publications/0018902571

U2 - 10.1016/0014-2999(80)90278-2

DO - 10.1016/0014-2999(80)90278-2

M3 - Article

C2 - 7379842

AN - SCOPUS:0018902571

SN - 0014-2999

VL - 62

SP - 209

EP - 213

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

Effect of kainate on ATP levels and glutamate metabolism in cerebellar slices

Abstract

Keywords

Access to Document

Fingerprint

Cite this