TY - JOUR
T1 - Effect of intra-operative fluid volume on peri-operative outcomes after pancreaticoduodenectomy for pancreatic adenocarcinoma
AU - Melis, Marcovalerio
AU - Marcon, Francesca
AU - Masi, Antonio
AU - Sarpel, Umut
AU - Miller, George
AU - Moore, Harvey
AU - Cohen, Steven
AU - Berman, Russell
AU - Pachter, H. Leon
AU - Newman, Elliot
PY - 2012/1
Y1 - 2012/1
N2 - Background Excess use of intravenous fluid can increase post-operative complications. We examined the influence of intra-operative crystalloid (IOC) administration on complications following pancreaticodudenectomy (PD) for pancreatic adenocarcinoma. Methods We categorized 188 patients who underwent PD for adenocarcinoma (1990-2009) into two groups: Group I received <6,000ml and Group II received ≥6,000ml IOC. Differences between groups in length of stay, overall morbidity, and 30-day mortality were evaluated. Results There were 86 patients in Group I and 102 in Group II. Group I patients were older and with higher percentage of women, but similar in regards to performance status, ASA score, underlying comorbidities, and administration of neo-adjuvant treatment. Group II patients had longer operations, increased blood loss, and higher rates of intra-operative blood transfusions. There were two post-operative deaths, both in the Group II (P=0.5). Post-operative overall morbidity was 45.7%, without differences between the two groups (44.2% vs. 47.1%, P=0.7). Likewise, length of post-operative stay was similar in both groups (13.8 days vs. 14.5 days, P=0.5). Conclusions The volume of IOC increased with duration of surgery, intra-operative blood losses, and intra-operative blood transfusion, but did not correlate with post-operative morbidity.
AB - Background Excess use of intravenous fluid can increase post-operative complications. We examined the influence of intra-operative crystalloid (IOC) administration on complications following pancreaticodudenectomy (PD) for pancreatic adenocarcinoma. Methods We categorized 188 patients who underwent PD for adenocarcinoma (1990-2009) into two groups: Group I received <6,000ml and Group II received ≥6,000ml IOC. Differences between groups in length of stay, overall morbidity, and 30-day mortality were evaluated. Results There were 86 patients in Group I and 102 in Group II. Group I patients were older and with higher percentage of women, but similar in regards to performance status, ASA score, underlying comorbidities, and administration of neo-adjuvant treatment. Group II patients had longer operations, increased blood loss, and higher rates of intra-operative blood transfusions. There were two post-operative deaths, both in the Group II (P=0.5). Post-operative overall morbidity was 45.7%, without differences between the two groups (44.2% vs. 47.1%, P=0.7). Likewise, length of post-operative stay was similar in both groups (13.8 days vs. 14.5 days, P=0.5). Conclusions The volume of IOC increased with duration of surgery, intra-operative blood losses, and intra-operative blood transfusion, but did not correlate with post-operative morbidity.
KW - Intra-operative fluids
KW - Pancreticoduodenctomy
KW - Post-operative morbidity
UR - http://www.scopus.com/inward/record.url?scp=83555174310&partnerID=8YFLogxK
U2 - 10.1002/jso.22048
DO - 10.1002/jso.22048
M3 - Article
C2 - 21792977
AN - SCOPUS:83555174310
SN - 0022-4790
VL - 105
SP - 81
EP - 84
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 1
ER -