Effect of increased NaCl or KCl intake on response to chronic furosemide administration

T. Kahn, B. Von Albertini, M. Goldstein

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Studies were performed to evaluate the effects of increased NaCl or KCl intake on the electrolyte loss provoked by chronic furosemide administration. Six dogs on a regular electrolyte intake received furosemide 40 mg orally 3 times a day for 4 days. Six dogs were studied in control, with the addition of 130 meq NaCl to the intake, and with furosemide for 4 days while the NaCl administration was continued. Similar studies were performed in seven dogs with 130 meq of KCl added to the daily intake. Over the 4-day period of furosemide administration with the regular electrolyte diet there was a significant increase in Na, Cl, and K excretion. With NaCl loading, daily Cl and Na excretion increased while K excretion was unchanged from control. Furosemide resulted in a lower increment of Cl and Na excretion on day 1 and a lower cumulative increment in Cl excretion over 4 days compared to dogs on the regular diet. During KCl loading, Cl and K excretion increased while Na excretion remained unchanged. The administration of furosemide resulted in no significant cumulative increment of Cl, K, or Na excretion over the 4-day period. Results in adrenalectomized dogs receiving steroid replacement were similar to normal dogs receiving KCl. These studies indicate that NaCl and KCl loading decreases, rather than increases, the electrolyte loss provoked by chronic furosemide administration.

Original languageEnglish
Pages (from-to)F509-F514
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume7
Issue number6
DOIs
StatePublished - 1980

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