Effect of Hydroxychloroquine on Influenza Prevention

Xingyue Huo, Joseph Finkelstein

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


The aim of this study was to assess whether long-term administration of hydroxychloroquine (HCQ) is protective from influenza in patients with rheumatoid arthritis and systemic lupus erythematosus. Using a propensity score-matched design, patients who were prescribed HCQ for more than 10 months were matched with patients of the same gender, age group, and Charlson Comorbidity Index score who did not receive HCQ. A logistic regression model was used to estimate the association between the HCQ exposure and influenza after adjusting for covariates. We found no evidence that long-term HCQ exposure can provide a protective effect against influenza during an influenza season.

Original languageEnglish
Title of host publicationAdvances in Informatics, Management and Technology in Healthcare
EditorsJohn Mantas, Parisis Gallos, Emmanouil Zoulias, Arie Hasman, Mowafa S. Househ, Marianna Diomidous, Joseph Liaskos, Martha Charalampidou
PublisherIOS Press BV
Number of pages2
ISBN (Electronic)9781643682907
StatePublished - 2022

Publication series

NameStudies in Health Technology and Informatics
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365


  • Hydroxychloroquine
  • MarketScan
  • case-control design
  • influenza


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