Effect of flutamide on cortisol metabolism*

David K. Fukushima, Joseph Levin, Jacob Kream, Selwyn Z. Freed, Willet F. Whitmore, Leon Hellman, Barnett Zumoff

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The effect of flutamide on cortisol metabolism was studied in eight patients with prostate cancer. Flutamide markedly decreased the formation of 3a,17,21-trihydroxypregnane-ll,20-dione (THE), 3α,- llβ,17,21-tetrahydroxypregnan-20-one (THF), and the ll-oxy-17-ketosteroid metabolites by 72%, 50%, and 46% respectively; however, 3α, llβ,17,21-tetrahydroxy-5apregnan- 20-one was increased by 46%. The 24-h mean plasma cortisol concentration was not altered. The cortisol production rate decreased by an average of 53% (from 32.7 to 15.5 mg/24 h). The effect of the drug on plasma cortisol kinetics was studied in three patients. This showed that flutamide increased the t½(from 80 to 108 min) but decreased the distribution volume (from 17.8 to 13.8 liters) and the MCR (from 222 to 130 liters/24 h). The changes in THE and THF formation and in the t½ and MCR of [14C]cortisol are simitar to the effects observed in patients with intrahepatic cholestasis. It is suggested that in the case of flutamide these changes were also due to a cholestasis-producing effect of the drug on the liver. As the clinical response to the drug did not correlate with the cortisol metabolic changes, its therapeutic effect was probably not mediated by its effects on cortisol metabolism.

Original languageEnglish
Pages (from-to)788-791
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume47
Issue number4
DOIs
StatePublished - Oct 1978
Externally publishedYes

Fingerprint

Dive into the research topics of 'Effect of flutamide on cortisol metabolism*'. Together they form a unique fingerprint.

Cite this