Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice

W. I. Rosenblum; E. F. Ellis; C. Cockrell

doi:10.1016/0049-3848(82)90096-2

Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice

W. I. Rosenblum
, E. F. Ellis
, C. Cockrell

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Washed mouse platelets produced thromboxane B₂ (TXB₂) and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) in vitro from tritiated arachidonic acid. When diabetes was induced by injecting streptozotocin i.p 200 mg/kg the TXB₂ production fell significantly and 12-HETE production significantly increased compared with that of control animals. Eighteen hours of food deprivation caused significant reductions in TXB₂ and 12-HETE production in both the control and diabetic groups.

Original language	English
Pages (from-to)	713-719
Number of pages	7
Journal	Thrombosis Research
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/0049-3848(82)90096-2
State	Published - 15 Dec 1982
Externally published	Yes

Keywords

Thromboxane
diabetes
fasting
lipoxygenase
mouse
platelets

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10.1016/0049-3848(82)90096-2

Cite this

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title = "Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice",

abstract = "Washed mouse platelets produced thromboxane B2 (TXB2) and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) in vitro from tritiated arachidonic acid. When diabetes was induced by injecting streptozotocin i.p 200 mg/kg the TXB2 production fell significantly and 12-HETE production significantly increased compared with that of control animals. Eighteen hours of food deprivation caused significant reductions in TXB2 and 12-HETE production in both the control and diabetic groups.",

keywords = "Thromboxane, diabetes, fasting, lipoxygenase, mouse, platelets",

author = "Rosenblum, \{W. I.\} and Ellis, \{E. F.\} and C. Cockrell",

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doi = "10.1016/0049-3848(82)90096-2",

language = "English",

volume = "28",

pages = "713--719",

journal = "Thrombosis Research",

issn = "0049-3848",

publisher = "Elsevier Ltd.",

number = "6",

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Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice. / Rosenblum, W. I.; Ellis, E. F.; Cockrell, C.
In: Thrombosis Research, Vol. 28, No. 6, 15.12.1982, p. 713-719.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice

AU - Rosenblum, W. I.

AU - Ellis, E. F.

AU - Cockrell, C.

PY - 1982/12/15

Y1 - 1982/12/15

N2 - Washed mouse platelets produced thromboxane B2 (TXB2) and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) in vitro from tritiated arachidonic acid. When diabetes was induced by injecting streptozotocin i.p 200 mg/kg the TXB2 production fell significantly and 12-HETE production significantly increased compared with that of control animals. Eighteen hours of food deprivation caused significant reductions in TXB2 and 12-HETE production in both the control and diabetic groups.

AB - Washed mouse platelets produced thromboxane B2 (TXB2) and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) in vitro from tritiated arachidonic acid. When diabetes was induced by injecting streptozotocin i.p 200 mg/kg the TXB2 production fell significantly and 12-HETE production significantly increased compared with that of control animals. Eighteen hours of food deprivation caused significant reductions in TXB2 and 12-HETE production in both the control and diabetic groups.

KW - Thromboxane

KW - diabetes

KW - fasting

KW - lipoxygenase

KW - mouse

KW - platelets

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ER -

Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice

Abstract

Keywords

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