Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice

W. I. Rosenblum; E. F. Ellis; C. Cockrell

doi:10.1016/0049-3848(82)90096-2

Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice

W. I. Rosenblum, E. F. Ellis, C. Cockrell

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Washed mouse platelets produced thromboxane B₂ (TXB₂) and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) in vitro from tritiated arachidonic acid. When diabetes was induced by injecting streptozotocin i.p 200 mg/kg the TXB₂ production fell significantly and 12-HETE production significantly increased compared with that of control animals. Eighteen hours of food deprivation caused significant reductions in TXB₂ and 12-HETE production in both the control and diabetic groups.

Original language	English
Pages (from-to)	713-719
Number of pages	7
Journal	Thrombosis Research
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/0049-3848(82)90096-2
State	Published - 15 Dec 1982
Externally published	Yes

Keywords

Thromboxane
diabetes
fasting
lipoxygenase
mouse
platelets

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10.1016/0049-3848(82)90096-2

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title = "Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice",

abstract = "Washed mouse platelets produced thromboxane B2 (TXB2) and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) in vitro from tritiated arachidonic acid. When diabetes was induced by injecting streptozotocin i.p 200 mg/kg the TXB2 production fell significantly and 12-HETE production significantly increased compared with that of control animals. Eighteen hours of food deprivation caused significant reductions in TXB2 and 12-HETE production in both the control and diabetic groups.",

keywords = "Thromboxane, diabetes, fasting, lipoxygenase, mouse, platelets",

author = "Rosenblum, {W. I.} and Ellis, {E. F.} and C. Cockrell",

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Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice. / Rosenblum, W. I.; Ellis, E. F.; Cockrell, C.
In: Thrombosis Research, Vol. 28, No. 6, 15.12.1982, p. 713-719.

Research output: Contribution to journal › Article › peer-review

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T1 - Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice

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AU - Ellis, E. F.

AU - Cockrell, C.

PY - 1982/12/15

Y1 - 1982/12/15

N2 - Washed mouse platelets produced thromboxane B2 (TXB2) and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) in vitro from tritiated arachidonic acid. When diabetes was induced by injecting streptozotocin i.p 200 mg/kg the TXB2 production fell significantly and 12-HETE production significantly increased compared with that of control animals. Eighteen hours of food deprivation caused significant reductions in TXB2 and 12-HETE production in both the control and diabetic groups.

AB - Washed mouse platelets produced thromboxane B2 (TXB2) and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) in vitro from tritiated arachidonic acid. When diabetes was induced by injecting streptozotocin i.p 200 mg/kg the TXB2 production fell significantly and 12-HETE production significantly increased compared with that of control animals. Eighteen hours of food deprivation caused significant reductions in TXB2 and 12-HETE production in both the control and diabetic groups.

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Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-eicosatetraenoic acid (12-hete) by washed platelets of normal and streptozotocin diabetic mice

Abstract

Keywords

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