Effect of exercise and heat exposure on percutaneous absorption of methyl salicylate

A. Danon, S. Ben-Shimon, Z. Ben-Zvi

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The effects of exercise, heat exposure or both on the percutaneous absorption of methyl salicylate were studied in 6 healthy volunteers. Exercise was performed to 30% ofVO2max, 45 min each hour for 6 h, at ambient temperatures of 22°C or 40°C. Systemic availability was assessed by measurement of plasma salicylate concentrations and cumulative urinary salicyluric acid excretion over an 8-h collection period. The absorption of methyl salicylate was increased to more than 3-times above control in subjects exercising in the heat. It is concluded that exercise and heat exposure, by increasing skin temperature, hydration and blood flow, enhance the percutaneous absorption of methyl salicylate.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Volume31
Issue number1
DOIs
StatePublished - Jan 1986
Externally publishedYes

Keywords

  • exercise
  • heat exposure
  • methyl salicylate
  • skin absorption

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