Effect of environmental toxicants on the epigenome and current applications

Diddier Prada; Andrea A. Baccarelli

doi:10.1016/B978-0-12-824010-6.00033-2

Effect of environmental toxicants on the epigenome and current applications

Diddier Prada, Andrea A. Baccarelli

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The epigenome, the collection of all the epigenetic marks, is highly susceptible to environmental exposures. In this chapter, we provide an overview of the most studied epigenetic marks that may be affected by environmental toxicants. We review epigenomic effects of metals, air pollution, persistent organic pollutants (POPs), endocrine disruptors, and the exposome. We also discuss environmental epigenomics in the context of precision medicine and the potential of epigenomic changes as early biomarkers of environmentally related health disorders. We conclude by discussing recent developments in assessing past exposures using epigenome-wide scanning and evaluating age acceleration.

Original language	English
Title of host publication	Comprehensive Precision Medicine, First Edition, Volume 1-2
Publisher	Elsevier
Pages	V1-453-V1-464
Volume	1-2
ISBN (Electronic)	9780128240106
DOIs	https://doi.org/10.1016/B978-0-12-824010-6.00033-2
State	Published - 1 Jan 2023
Externally published	Yes

Keywords

Age acceleration
Air pollution
Applications
Chromatin
DNA methylation
Endocrine disruptors
Environmental
Epidemiological
Epigenome
Exposome
Histone modifications
Metals
POPs
Toxicants
ncRNAs

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10.1016/B978-0-12-824010-6.00033-2

Cite this

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abstract = "The epigenome, the collection of all the epigenetic marks, is highly susceptible to environmental exposures. In this chapter, we provide an overview of the most studied epigenetic marks that may be affected by environmental toxicants. We review epigenomic effects of metals, air pollution, persistent organic pollutants (POPs), endocrine disruptors, and the exposome. We also discuss environmental epigenomics in the context of precision medicine and the potential of epigenomic changes as early biomarkers of environmentally related health disorders. We conclude by discussing recent developments in assessing past exposures using epigenome-wide scanning and evaluating age acceleration.",

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AB - The epigenome, the collection of all the epigenetic marks, is highly susceptible to environmental exposures. In this chapter, we provide an overview of the most studied epigenetic marks that may be affected by environmental toxicants. We review epigenomic effects of metals, air pollution, persistent organic pollutants (POPs), endocrine disruptors, and the exposome. We also discuss environmental epigenomics in the context of precision medicine and the potential of epigenomic changes as early biomarkers of environmentally related health disorders. We conclude by discussing recent developments in assessing past exposures using epigenome-wide scanning and evaluating age acceleration.

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KW - DNA methylation

KW - Endocrine disruptors

KW - Environmental

KW - Epidemiological

KW - Epigenome

KW - Exposome

KW - Histone modifications

KW - Metals

KW - POPs

KW - Toxicants

KW - ncRNAs

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M3 - Chapter

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SP - V1-453-V1-464

BT - Comprehensive Precision Medicine, First Edition, Volume 1-2

PB - Elsevier

ER -

Effect of environmental toxicants on the epigenome and current applications

Abstract

Keywords

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