TY - JOUR
T1 - Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status
T2 - A mendelian randomisation approach
AU - Brennan, Paul
AU - Hsu, Charles C.
AU - Moullan, Norman
AU - Szeszenia-Dabrowska, Neonilia
AU - Lissowska, Jolanta
AU - Zaridze, David
AU - Rudnai, Peter
AU - Fabianova, Eleonora
AU - Mates, Dana
AU - Bencko, Vladimir
AU - Foretova, Lenka
AU - Janout, Vladimir
AU - Gemignani, Federica
AU - Chabrier, Amelie
AU - Hall, Janet
AU - Hung, Rayjean J.
AU - Boffetta, Paolo
AU - Canzian, Federico
N1 - Funding Information:
Interviewee recruitment was supported by a grant from the European Commission's INCO-COPERNICUS Programme (contract # IC15-CT96-0313). Genotyping and analysis was funded by a National Cancer Institute R01 grant (contract # CA 092039-01A2). Neither funding agency had any involvement in the study design, collection, analysis, and interpretation of the data or in the writing of the report and decision to submit the paper. C C Hsu was supported by a Postdoctoral Fellowship from the International Agency for Research on Cancer. F Gemignani is a recipient of a fellowship of the International Association for the Study of Lung Cancer (IASLC), part of the Cancer Research Foundation of America (CRFA).
PY - 2005/10/29
Y1 - 2005/10/29
N2 - Whether consumption of cruciferous vegetables protects against lung cancer is unclear, largely because of potential confounding factors. We therefore studied the role of cruciferous vegetables in lung cancer after stratifying by GSTM1 and GSTT1 status, two genes implicated in the elimination of isothiocyanates, the likely chemopreventative compound. In 2141 cases and 2168 controls, weekly consumption of cruciferous vegetables protected against lung cancer in those who were GSTM1 null (odds ratio=0·67, 95% CI 0·49-0·91), GSTT1 null (0·63, 0·37-1·07), or both (0·28, 0·11-0·67). No protective effect was seen in people who were both GSTM1 and GSTT1 positive (0·88, 0·65- 1·21). Similar protective results were noted for consumption of cabbage and a combination of broccoli and brussels sprouts. These data provide strong evidence for a substantial protective effect of cruciferous vegetable consumption on lung cancer.
AB - Whether consumption of cruciferous vegetables protects against lung cancer is unclear, largely because of potential confounding factors. We therefore studied the role of cruciferous vegetables in lung cancer after stratifying by GSTM1 and GSTT1 status, two genes implicated in the elimination of isothiocyanates, the likely chemopreventative compound. In 2141 cases and 2168 controls, weekly consumption of cruciferous vegetables protected against lung cancer in those who were GSTM1 null (odds ratio=0·67, 95% CI 0·49-0·91), GSTT1 null (0·63, 0·37-1·07), or both (0·28, 0·11-0·67). No protective effect was seen in people who were both GSTM1 and GSTT1 positive (0·88, 0·65- 1·21). Similar protective results were noted for consumption of cabbage and a combination of broccoli and brussels sprouts. These data provide strong evidence for a substantial protective effect of cruciferous vegetable consumption on lung cancer.
UR - http://www.scopus.com/inward/record.url?scp=27544498543&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(05)67628-3
DO - 10.1016/S0140-6736(05)67628-3
M3 - Article
C2 - 16257343
AN - SCOPUS:27544498543
SN - 0140-6736
VL - 366
SP - 1558
EP - 1560
JO - The Lancet
JF - The Lancet
IS - 9496
ER -