TY - JOUR
T1 - Effect of chronic ethanol ingestion on mitochondrial permeability and the transport of reducing equivalents
AU - Cederbaum, Arthur I.
AU - Lieber, Charles S.
AU - Beattie, Diana S.
AU - Rubin, Emanuel
PY - 1972/11/1
Y1 - 1972/11/1
N2 - Chronic ethanol feeding to rats leads to an increased rate of ethanol metabolism. This increase is not accompanied by altered permeability of the mitochondria to NADH. The activities of the reconstituted malate-aspartate, fatty acid elongation and α-glycerophosphate shuttles for the transport of reducing equivalents into mitochondria were not changed by chronic ethanol ingestion. Thus, in contrast to other reports, these results show that neither increased mitochondrial permeability nor enhanced shuttle activity explains the acceleration of ethanol metabolism produced by chronic ethanol ingestion.
AB - Chronic ethanol feeding to rats leads to an increased rate of ethanol metabolism. This increase is not accompanied by altered permeability of the mitochondria to NADH. The activities of the reconstituted malate-aspartate, fatty acid elongation and α-glycerophosphate shuttles for the transport of reducing equivalents into mitochondria were not changed by chronic ethanol ingestion. Thus, in contrast to other reports, these results show that neither increased mitochondrial permeability nor enhanced shuttle activity explains the acceleration of ethanol metabolism produced by chronic ethanol ingestion.
UR - http://www.scopus.com/inward/record.url?scp=0015420927&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(72)90460-3
DO - 10.1016/0006-291X(72)90460-3
M3 - Article
C2 - 4344683
AN - SCOPUS:0015420927
SN - 0006-291X
VL - 49
SP - 649
EP - 655
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -