Effect of adjuvant central iv hyperalimentation on the survival and response to treatment of patients with small cell lung cancer: A randomized trial

G. H. Clamon, R. Feld, W. K. Evans, R. S. Weiner, E. M. Moran, R. H. Blum, B. S. Kramer, R. W. Makuch, F. A. Hoffman, W. D. DeWys

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68 Scopus citations

Abstract

The effect of central iv hyperalimentation (IVH) as an adjunct to aggressive antineoplastic therapy for small cell carcinoma of the lung was evaluated in a randomized trial with 119 evaluable patients. IVH was given over a 28-day period with higher caloric and protein intake for patients nutritionally depleted on entry in the study; all patients were escalated in caloric and protein intake to maximize nutritional repletion. Combination chemotherapy and radiation therapy induced a 45.5% complete response rate and an overall response rate of 92.8%. Median survival for patients with limited disease was 18 months; median survival for patients with extensive disease was 11 months. Patients randomized to receive IVH did not have a better response rate (P = 0.97) or survival (P = 0.78) than control patients. IVH did not significantly alter the survival for patients who at baseline had > 5% pretreatment weight loss, low caloric intake, decreased serum albumin, or reduced total iron-binding capacity. Significantly more febrile episodes were seen in IVH patients than in control patients (P < 0.001). Short-term IVH to patients with this malignancy who are capable of enteral alimentation cannot be routinely recommended as adjunctive therapy.

Original languageEnglish
Pages (from-to)167-177
Number of pages11
JournalCancer Treatment Reports
Volume69
Issue number2
StatePublished - 1985

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