Effect of acute blood loss on glycosylated hemoglobin determinations in normal subjects

H. S. Starkman; M. Wacks; J. S. Soeldner; A. Kim

doi:10.2337/diacare.6.3.291

Effect of acute blood loss on glycosylated hemoglobin determinations in normal subjects

H. S. Starkman, M. Wacks, J. S. Soeldner, A. Kim

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19 Scopus citations

Abstract

Nondiabetic adult subjects (N = 12) were studied to determine the effect of an approximately 450-ml acute blood loss upon glycosylated hemoglobin measurements. After blood loss, the hematocrit significantly decreased by week 1 (P < 0.001) and the reticulocyte count peaked by week 2. All glycosylated hemoglobins measured showed significant decreases post blood loss. The nadir was at week 4 for total A₁, A(lc), and irreversible A(lc) by high-pressure liquid chromatography (HPLC), and at week 6 for irreversible A₁ by HPLC and A₁ by electrophoresis. The mean percent decrease in glycosylated hemoglobins ranged from 4.6% (irreversible A₁ by HPLC) to 8.6% (total A(lc) by HPLC).

Original language	English
Pages (from-to)	291-294
Number of pages	4
Journal	Diabetes Care
Volume	6
Issue number	3
DOIs	https://doi.org/10.2337/diacare.6.3.291
State	Published - 1983
Externally published	Yes

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title = "Effect of acute blood loss on glycosylated hemoglobin determinations in normal subjects",

abstract = "Nondiabetic adult subjects (N = 12) were studied to determine the effect of an approximately 450-ml acute blood loss upon glycosylated hemoglobin measurements. After blood loss, the hematocrit significantly decreased by week 1 (P < 0.001) and the reticulocyte count peaked by week 2. All glycosylated hemoglobins measured showed significant decreases post blood loss. The nadir was at week 4 for total A1, A(lc), and irreversible A(lc) by high-pressure liquid chromatography (HPLC), and at week 6 for irreversible A1 by HPLC and A1 by electrophoresis. The mean percent decrease in glycosylated hemoglobins ranged from 4.6% (irreversible A1 by HPLC) to 8.6% (total A(lc) by HPLC).",

author = "Starkman, {H. S.} and M. Wacks and Soeldner, {J. S.} and A. Kim",

year = "1983",

doi = "10.2337/diacare.6.3.291",

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T1 - Effect of acute blood loss on glycosylated hemoglobin determinations in normal subjects

AU - Starkman, H. S.

AU - Wacks, M.

AU - Soeldner, J. S.

AU - Kim, A.

PY - 1983

Y1 - 1983

N2 - Nondiabetic adult subjects (N = 12) were studied to determine the effect of an approximately 450-ml acute blood loss upon glycosylated hemoglobin measurements. After blood loss, the hematocrit significantly decreased by week 1 (P < 0.001) and the reticulocyte count peaked by week 2. All glycosylated hemoglobins measured showed significant decreases post blood loss. The nadir was at week 4 for total A1, A(lc), and irreversible A(lc) by high-pressure liquid chromatography (HPLC), and at week 6 for irreversible A1 by HPLC and A1 by electrophoresis. The mean percent decrease in glycosylated hemoglobins ranged from 4.6% (irreversible A1 by HPLC) to 8.6% (total A(lc) by HPLC).

AB - Nondiabetic adult subjects (N = 12) were studied to determine the effect of an approximately 450-ml acute blood loss upon glycosylated hemoglobin measurements. After blood loss, the hematocrit significantly decreased by week 1 (P < 0.001) and the reticulocyte count peaked by week 2. All glycosylated hemoglobins measured showed significant decreases post blood loss. The nadir was at week 4 for total A1, A(lc), and irreversible A(lc) by high-pressure liquid chromatography (HPLC), and at week 6 for irreversible A1 by HPLC and A1 by electrophoresis. The mean percent decrease in glycosylated hemoglobins ranged from 4.6% (irreversible A1 by HPLC) to 8.6% (total A(lc) by HPLC).

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SN - 0149-5992

VL - 6

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EP - 294

JO - Diabetes Care

JF - Diabetes Care

IS - 3

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Effect of acute blood loss on glycosylated hemoglobin determinations in normal subjects

Abstract

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