Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis

Evan S. Wu; Jong Y. Park; Joseph A. Zeitouni; Carmen R. Gomez; Isildinha M. Reis; Wei Zhao; Deukwoo Kwon; Eunkyung Lee; Omar L. Nelson; Hui Yi Lin; Elizabeth J. Franzmann; Jason Savell; Thomas V. McCaffrey; W. Jarrard Goodwin; Jennifer J. Hu

doi:10.1002/hed.24420

Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis

Evan S. Wu, Jong Y. Park, Joseph A. Zeitouni, Carmen R. Gomez, Isildinha M. Reis, Wei Zhao, Deukwoo Kwon, Eunkyung Lee, Omar L. Nelson, Hui Yi Lin, Elizabeth J. Franzmann, Jason Savell, Thomas V. McCaffrey, W. Jarrard Goodwin, Jennifer J. Hu

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and minorities have the worst survival. However, the molecular mechanisms underlying survival disparities have not been elucidated. Methods: In a retrospective study, we assessed association between HNSCC early death (<2 years) and 208 somatic mutations of 10 cancer-related genes in 214 patients: 98 non-Hispanic whites (46%), 72 Hispanic whites (34%), and 44 African Americans (20%). Results: Hispanic whites and African Americans had significantly higher mutation rates for EGFR, HRAS, KRAS, and TP53. HNSCC early death was significantly associated with 3+ mutations (odds ratio [OR] = 2.78, 95% confidence interval [CI] = 1.16, 6.69), NOTCH1 mutations in non-Hispanic whites (OR = 5.51; 95% CI = 1.22–24.83) and TP53 mutations in Hispanic whites (OR = 3.84; 95% CI = 1.08–13.68) in multivariable analysis adjusted for age, sex, tumor site, and tumor stage. Conclusion: We have provided the proof-of-principal data to link racial/ethnic-specific somatic mutations and HNSCC prognosis and pave the way for precision medicine to overcome HNSCC survival disparities.

Original language	English
Pages (from-to)	1234-1241
Number of pages	8
Journal	Head and Neck
Volume	38
Issue number	8
DOIs	https://doi.org/10.1002/hed.24420
State	Published - 1 Aug 2016
Externally published	Yes

Keywords

cancer disparities
head and neck squamous cell carcinoma (HNSCC)
precision medicine
prognosis
somatic mutations

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Wu, E. S., Park, J. Y., Zeitouni, J. A., Gomez, C. R., Reis, I. M., Zhao, W., Kwon, D., Lee, E., Nelson, O. L., Lin, H. Y., Franzmann, E. J., Savell, J., McCaffrey, T. V., Goodwin, W. J., & Hu, J. J. (2016). Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis. Head and Neck, 38(8), 1234-1241. https://doi.org/10.1002/hed.24420

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title = "Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis",

abstract = "Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and minorities have the worst survival. However, the molecular mechanisms underlying survival disparities have not been elucidated. Methods: In a retrospective study, we assessed association between HNSCC early death (<2 years) and 208 somatic mutations of 10 cancer-related genes in 214 patients: 98 non-Hispanic whites (46%), 72 Hispanic whites (34%), and 44 African Americans (20%). Results: Hispanic whites and African Americans had significantly higher mutation rates for EGFR, HRAS, KRAS, and TP53. HNSCC early death was significantly associated with 3+ mutations (odds ratio [OR] = 2.78, 95% confidence interval [CI] = 1.16, 6.69), NOTCH1 mutations in non-Hispanic whites (OR = 5.51; 95% CI = 1.22–24.83) and TP53 mutations in Hispanic whites (OR = 3.84; 95% CI = 1.08–13.68) in multivariable analysis adjusted for age, sex, tumor site, and tumor stage. Conclusion: We have provided the proof-of-principal data to link racial/ethnic-specific somatic mutations and HNSCC prognosis and pave the way for precision medicine to overcome HNSCC survival disparities.",

keywords = "cancer disparities, head and neck squamous cell carcinoma (HNSCC), precision medicine, prognosis, somatic mutations",

author = "Wu, {Evan S.} and Park, {Jong Y.} and Zeitouni, {Joseph A.} and Gomez, {Carmen R.} and Reis, {Isildinha M.} and Wei Zhao and Deukwoo Kwon and Eunkyung Lee and Nelson, {Omar L.} and Lin, {Hui Yi} and Franzmann, {Elizabeth J.} and Jason Savell and McCaffrey, {Thomas V.} and Goodwin, {W. Jarrard} and Hu, {Jennifer J.}",

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doi = "10.1002/hed.24420",

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AU - Wu, Evan S.

AU - Park, Jong Y.

AU - Zeitouni, Joseph A.

AU - Gomez, Carmen R.

AU - Reis, Isildinha M.

AU - Zhao, Wei

AU - Kwon, Deukwoo

AU - Lee, Eunkyung

AU - Nelson, Omar L.

AU - Lin, Hui Yi

AU - Franzmann, Elizabeth J.

AU - Savell, Jason

AU - McCaffrey, Thomas V.

AU - Goodwin, W. Jarrard

AU - Hu, Jennifer J.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and minorities have the worst survival. However, the molecular mechanisms underlying survival disparities have not been elucidated. Methods: In a retrospective study, we assessed association between HNSCC early death (<2 years) and 208 somatic mutations of 10 cancer-related genes in 214 patients: 98 non-Hispanic whites (46%), 72 Hispanic whites (34%), and 44 African Americans (20%). Results: Hispanic whites and African Americans had significantly higher mutation rates for EGFR, HRAS, KRAS, and TP53. HNSCC early death was significantly associated with 3+ mutations (odds ratio [OR] = 2.78, 95% confidence interval [CI] = 1.16, 6.69), NOTCH1 mutations in non-Hispanic whites (OR = 5.51; 95% CI = 1.22–24.83) and TP53 mutations in Hispanic whites (OR = 3.84; 95% CI = 1.08–13.68) in multivariable analysis adjusted for age, sex, tumor site, and tumor stage. Conclusion: We have provided the proof-of-principal data to link racial/ethnic-specific somatic mutations and HNSCC prognosis and pave the way for precision medicine to overcome HNSCC survival disparities.

AB - Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and minorities have the worst survival. However, the molecular mechanisms underlying survival disparities have not been elucidated. Methods: In a retrospective study, we assessed association between HNSCC early death (<2 years) and 208 somatic mutations of 10 cancer-related genes in 214 patients: 98 non-Hispanic whites (46%), 72 Hispanic whites (34%), and 44 African Americans (20%). Results: Hispanic whites and African Americans had significantly higher mutation rates for EGFR, HRAS, KRAS, and TP53. HNSCC early death was significantly associated with 3+ mutations (odds ratio [OR] = 2.78, 95% confidence interval [CI] = 1.16, 6.69), NOTCH1 mutations in non-Hispanic whites (OR = 5.51; 95% CI = 1.22–24.83) and TP53 mutations in Hispanic whites (OR = 3.84; 95% CI = 1.08–13.68) in multivariable analysis adjusted for age, sex, tumor site, and tumor stage. Conclusion: We have provided the proof-of-principal data to link racial/ethnic-specific somatic mutations and HNSCC prognosis and pave the way for precision medicine to overcome HNSCC survival disparities.

KW - cancer disparities

KW - head and neck squamous cell carcinoma (HNSCC)

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JO - Head and Neck

JF - Head and Neck

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Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis

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Keywords

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