Effect of acorus tatarinowii schott on ultrastructure and permeability of blood-brain barrier

Yuan Hu, Mo Yuan, Ping Liu, Lihua Mu, Hong Wang

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Objective: To explore the influence of Acorus tatarinowii schott on ultrastructure and permeability of BBB. Method: The ultrastructure and permeability of BBB on rats with A. tatarinowii by electron microscope were observed. The even's blue (EB) and sodium phenytoin in brain was determined by UV and HPLC-MS. Result: After give A. tatarinowii, tight junctions of the endothelial cell opened in cotex, and the concentration of EB and sodium phenytoin in brain are significant increased. Conclusion: A. tatarinowii can increase the permeability of BBB. and show its 'Kaiqiao' effect.

Original languageEnglish
Pages (from-to)349-351
Number of pages3
JournalZhongguo Zhongyao Zazhi
Volume34
Issue number3
StatePublished - Feb 2009
Externally publishedYes

Keywords

  • Blood-brain barrier
  • Kaiqiao
  • Permeability
  • Ultrastructure

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