Effect of 5-methylurapidil (5-MU) on aqueous humor dynamics in monkeys and rabbits

R. F. Wang; P. Y. Lee; T. W. Mittag; S. M. Podos; J. B. Serle

Effect of 5-methylurapidil (5-MU) on aqueous humor dynamics in monkeys and rabbits

R. F. Wang, P. Y. Lee, T. W. Mittag, S. M. Podos, J. B. Serle

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose. 5-MU, an α_1A-adrenergic antagonist and 5-hydroxytryptamine (serotonin) agonist, reduces intraocular pressure (IOP) and pupil size in normal and glaucomatous eyes of monkeys. An investigation was carried out to determine the mechanism by which 5-MU reduces IOP when applied topically. Methods. Before and after unilateral application of 50μl of 2% 5-MU, tonographic outflow facility (C) and fluorophotometric aqueous humor flow (F) were measured in 8 normal cynomolgus monkeys. Uveoscleral outflow facility (Fu) was measured by a perfusion technique with FITC-dextran in 8 rabbits. Results. Compared with baseline values, C was increased by 51% (P < 0.01) in the treated eyes, and 16% (P > 0.10) in the contralateral control eyes at 1 hr after a single dose of 2% 5-MU. F was increased by 11% (P < 0.01) over a period of 4 hrs in the treated eyes, and by 3% (P > 0.10) in the contralateral control eyes after drug administration. Fu was unchanged (P > 0.30) at 1 hr following a single dose application. Conclusion. 5-MU reduces IOP by increasing outflow facility.

Original language	English
Pages (from-to)	S836
Journal	Investigative Ophthalmology and Visual Science
Volume	37
Issue number	3
State	Published - 15 Feb 1996

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title = "Effect of 5-methylurapidil (5-MU) on aqueous humor dynamics in monkeys and rabbits",

abstract = "Purpose. 5-MU, an α1A-adrenergic antagonist and 5-hydroxytryptamine (serotonin) agonist, reduces intraocular pressure (IOP) and pupil size in normal and glaucomatous eyes of monkeys. An investigation was carried out to determine the mechanism by which 5-MU reduces IOP when applied topically. Methods. Before and after unilateral application of 50μl of 2% 5-MU, tonographic outflow facility (C) and fluorophotometric aqueous humor flow (F) were measured in 8 normal cynomolgus monkeys. Uveoscleral outflow facility (Fu) was measured by a perfusion technique with FITC-dextran in 8 rabbits. Results. Compared with baseline values, C was increased by 51% (P < 0.01) in the treated eyes, and 16% (P > 0.10) in the contralateral control eyes at 1 hr after a single dose of 2% 5-MU. F was increased by 11% (P < 0.01) over a period of 4 hrs in the treated eyes, and by 3% (P > 0.10) in the contralateral control eyes after drug administration. Fu was unchanged (P > 0.30) at 1 hr following a single dose application. Conclusion. 5-MU reduces IOP by increasing outflow facility.",

author = "Wang, {R. F.} and Lee, {P. Y.} and Mittag, {T. W.} and Podos, {S. M.} and Serle, {J. B.}",

year = "1996",

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language = "English",

volume = "37",

pages = "S836",

journal = "Investigative Ophthalmology and Visual Science",

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T1 - Effect of 5-methylurapidil (5-MU) on aqueous humor dynamics in monkeys and rabbits

AU - Wang, R. F.

AU - Lee, P. Y.

AU - Mittag, T. W.

AU - Podos, S. M.

AU - Serle, J. B.

PY - 1996/2/15

Y1 - 1996/2/15

N2 - Purpose. 5-MU, an α1A-adrenergic antagonist and 5-hydroxytryptamine (serotonin) agonist, reduces intraocular pressure (IOP) and pupil size in normal and glaucomatous eyes of monkeys. An investigation was carried out to determine the mechanism by which 5-MU reduces IOP when applied topically. Methods. Before and after unilateral application of 50μl of 2% 5-MU, tonographic outflow facility (C) and fluorophotometric aqueous humor flow (F) were measured in 8 normal cynomolgus monkeys. Uveoscleral outflow facility (Fu) was measured by a perfusion technique with FITC-dextran in 8 rabbits. Results. Compared with baseline values, C was increased by 51% (P < 0.01) in the treated eyes, and 16% (P > 0.10) in the contralateral control eyes at 1 hr after a single dose of 2% 5-MU. F was increased by 11% (P < 0.01) over a period of 4 hrs in the treated eyes, and by 3% (P > 0.10) in the contralateral control eyes after drug administration. Fu was unchanged (P > 0.30) at 1 hr following a single dose application. Conclusion. 5-MU reduces IOP by increasing outflow facility.

AB - Purpose. 5-MU, an α1A-adrenergic antagonist and 5-hydroxytryptamine (serotonin) agonist, reduces intraocular pressure (IOP) and pupil size in normal and glaucomatous eyes of monkeys. An investigation was carried out to determine the mechanism by which 5-MU reduces IOP when applied topically. Methods. Before and after unilateral application of 50μl of 2% 5-MU, tonographic outflow facility (C) and fluorophotometric aqueous humor flow (F) were measured in 8 normal cynomolgus monkeys. Uveoscleral outflow facility (Fu) was measured by a perfusion technique with FITC-dextran in 8 rabbits. Results. Compared with baseline values, C was increased by 51% (P < 0.01) in the treated eyes, and 16% (P > 0.10) in the contralateral control eyes at 1 hr after a single dose of 2% 5-MU. F was increased by 11% (P < 0.01) over a period of 4 hrs in the treated eyes, and by 3% (P > 0.10) in the contralateral control eyes after drug administration. Fu was unchanged (P > 0.30) at 1 hr following a single dose application. Conclusion. 5-MU reduces IOP by increasing outflow facility.

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SN - 0146-0404

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JO - Investigative Ophthalmology and Visual Science

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Effect of 5-methylurapidil (5-MU) on aqueous humor dynamics in monkeys and rabbits

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