EDSS 0 is not normal: Multiple sclerosis disease burden below the clinical threshold

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Abstract

Little to no above-threshold deficits may be evident in early multiple sclerosis (MS). The Expanded Disability Status Scale (EDSS) is a standard measure of neurologic function, with an EDSS score of 0 defined as “neurologically normal.” The topographical model of MS proposes that sub-threshold disease is compensated for by functional reserve. In this short report, we found that physically high-challenge measures of balance and upper extremity coordination reveal sub-threshold deficits in patients with EDSS score of 0 compared with healthy controls. Challenge task performance was correlated with imaging markers of both lesional burden of disease and a volumetric measure of brain reserve.

Original languageEnglish
Pages (from-to)2299-2303
Number of pages5
JournalMultiple Sclerosis Journal
Volume28
Issue number14
DOIs
StatePublished - Dec 2022

Keywords

  • EDSS
  • Multiple sclerosis
  • disease course
  • topographical model

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