ECT anesthesia: The lighter the better?

Alexander Sartorius; E. M. Muñoz-Canales; B. Krumm; A. Krier; F. J. Andres; H. J. Bender; F. A. Henn

doi:10.1055/s-2006-950395

ECT anesthesia: The lighter the better?

Alexander Sartorius, E. M. Muñoz-Canales, B. Krumm, A. Krier, F. J. Andres, H. J. Bender, F. A. Henn

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35 Scopus citations

Abstract

Background: Electroconvulsive therapy (ECT) is a most effective treatment for patients with major affective disorders. The influence of anesthetic drugs on seizure "adequacy" or on treatment success has not been systematically investigated. Methods: A bispectral EEG index score (BIS) was used to identify the depth of anesthesia during ECT. Our study included 22 major depressive episode (MDE) patients expanding to 219 ECTs (05/05-01/06) with no limitations of concurrent medication. Results: Fourteen out of the 22 patients showed full remission. Individual number of ECT sessions needed to reach full remission correlated negatively with mean pre-ECT BIS values (p = 0.001). Additionally, using a repeated measurement regression analysis significant correlations were found for pre-ECT BIS versus motor response time, seizure concordance, ictal coherence and peak heart rate. Conclusion: The results of our study suggest BIS-levels as a predictor of faster ECT response. Controlling BIS-levels before stimulation may have an additional effect on treatment success.

Original language	English
Pages (from-to)	201-204
Number of pages	4
Journal	Pharmacopsychiatry
Volume	39
Issue number	6
DOIs	https://doi.org/10.1055/s-2006-950395
State	Published - Nov 2006
Externally published	Yes

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title = "ECT anesthesia: The lighter the better?",

abstract = "Background: Electroconvulsive therapy (ECT) is a most effective treatment for patients with major affective disorders. The influence of anesthetic drugs on seizure {"}adequacy{"} or on treatment success has not been systematically investigated. Methods: A bispectral EEG index score (BIS) was used to identify the depth of anesthesia during ECT. Our study included 22 major depressive episode (MDE) patients expanding to 219 ECTs (05/05-01/06) with no limitations of concurrent medication. Results: Fourteen out of the 22 patients showed full remission. Individual number of ECT sessions needed to reach full remission correlated negatively with mean pre-ECT BIS values (p = 0.001). Additionally, using a repeated measurement regression analysis significant correlations were found for pre-ECT BIS versus motor response time, seizure concordance, ictal coherence and peak heart rate. Conclusion: The results of our study suggest BIS-levels as a predictor of faster ECT response. Controlling BIS-levels before stimulation may have an additional effect on treatment success.",

author = "Alexander Sartorius and Mu{\~n}oz-Canales, {E. M.} and B. Krumm and A. Krier and Andres, {F. J.} and Bender, {H. J.} and Henn, {F. A.}",

year = "2006",

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TY - JOUR

T1 - ECT anesthesia

T2 - The lighter the better?

AU - Sartorius, Alexander

AU - Muñoz-Canales, E. M.

AU - Krumm, B.

AU - Krier, A.

AU - Andres, F. J.

AU - Bender, H. J.

AU - Henn, F. A.

PY - 2006/11

Y1 - 2006/11

N2 - Background: Electroconvulsive therapy (ECT) is a most effective treatment for patients with major affective disorders. The influence of anesthetic drugs on seizure "adequacy" or on treatment success has not been systematically investigated. Methods: A bispectral EEG index score (BIS) was used to identify the depth of anesthesia during ECT. Our study included 22 major depressive episode (MDE) patients expanding to 219 ECTs (05/05-01/06) with no limitations of concurrent medication. Results: Fourteen out of the 22 patients showed full remission. Individual number of ECT sessions needed to reach full remission correlated negatively with mean pre-ECT BIS values (p = 0.001). Additionally, using a repeated measurement regression analysis significant correlations were found for pre-ECT BIS versus motor response time, seizure concordance, ictal coherence and peak heart rate. Conclusion: The results of our study suggest BIS-levels as a predictor of faster ECT response. Controlling BIS-levels before stimulation may have an additional effect on treatment success.

AB - Background: Electroconvulsive therapy (ECT) is a most effective treatment for patients with major affective disorders. The influence of anesthetic drugs on seizure "adequacy" or on treatment success has not been systematically investigated. Methods: A bispectral EEG index score (BIS) was used to identify the depth of anesthesia during ECT. Our study included 22 major depressive episode (MDE) patients expanding to 219 ECTs (05/05-01/06) with no limitations of concurrent medication. Results: Fourteen out of the 22 patients showed full remission. Individual number of ECT sessions needed to reach full remission correlated negatively with mean pre-ECT BIS values (p = 0.001). Additionally, using a repeated measurement regression analysis significant correlations were found for pre-ECT BIS versus motor response time, seizure concordance, ictal coherence and peak heart rate. Conclusion: The results of our study suggest BIS-levels as a predictor of faster ECT response. Controlling BIS-levels before stimulation may have an additional effect on treatment success.

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SP - 201

EP - 204

JO - Pharmacopsychiatry

JF - Pharmacopsychiatry

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ER -

ECT anesthesia: The lighter the better?

Abstract

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