Ecological impact of isolated cognitive relapses in MS

Riccardo Meli; Luca Roccatagliata; Elisabetta Capello; Nicolò Bruschi; Antonio Uccelli; Gianluigi Mancardi; Matilde Inglese; Matteo Pardini

doi:10.1177/1352458518813722

Ecological impact of isolated cognitive relapses in MS

Riccardo Meli, Luca Roccatagliata, Elisabetta Capello, Nicolò Bruschi, Antonio Uccelli, Gianluigi Mancardi, Matilde Inglese, Matteo Pardini

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15 Scopus citations

Abstract

Isolated cognitive relapses (ICRs) are transient deficits in cognitive performance that are the only presentation of a multiple sclerosis (MS) relapse. Here, we evaluated the impact of ICRs on cognitive difficulties in daily activities (assessed with the Multiple Sclerosis Neuropsychological Screening Questionnaire, Informant Version (MSNQ-I)) to characterize ICRs’ clinical relevance. We used 2-year-long retrospective data to compare 15 relapsing-remitting MS (RRMS) patients with ICRs with 57 RRMS patients presenting an asymptomatic gadolinium enhancing lesion (and no-ICRs). ICRs were associated not only with neuropsychological performance decline but also with an increase in the daily cognitive difficulties. These findings support the ecological relevance of ICRs.

Original language	English
Pages (from-to)	114-117
Number of pages	4
Journal	Multiple Sclerosis Journal
Volume	26
Issue number	1
DOIs	https://doi.org/10.1177/1352458518813722
State	Published - 1 Jan 2020

Keywords

Relapses
cognition
quality of life

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title = "Ecological impact of isolated cognitive relapses in MS",

abstract = "Isolated cognitive relapses (ICRs) are transient deficits in cognitive performance that are the only presentation of a multiple sclerosis (MS) relapse. Here, we evaluated the impact of ICRs on cognitive difficulties in daily activities (assessed with the Multiple Sclerosis Neuropsychological Screening Questionnaire, Informant Version (MSNQ-I)) to characterize ICRs{\textquoteright} clinical relevance. We used 2-year-long retrospective data to compare 15 relapsing-remitting MS (RRMS) patients with ICRs with 57 RRMS patients presenting an asymptomatic gadolinium enhancing lesion (and no-ICRs). ICRs were associated not only with neuropsychological performance decline but also with an increase in the daily cognitive difficulties. These findings support the ecological relevance of ICRs.",

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AU - Meli, Riccardo

AU - Roccatagliata, Luca

AU - Capello, Elisabetta

AU - Bruschi, Nicolò

AU - Uccelli, Antonio

AU - Mancardi, Gianluigi

AU - Inglese, Matilde

AU - Pardini, Matteo

N1 - Publisher Copyright: © The Author(s), 2018.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Isolated cognitive relapses (ICRs) are transient deficits in cognitive performance that are the only presentation of a multiple sclerosis (MS) relapse. Here, we evaluated the impact of ICRs on cognitive difficulties in daily activities (assessed with the Multiple Sclerosis Neuropsychological Screening Questionnaire, Informant Version (MSNQ-I)) to characterize ICRs’ clinical relevance. We used 2-year-long retrospective data to compare 15 relapsing-remitting MS (RRMS) patients with ICRs with 57 RRMS patients presenting an asymptomatic gadolinium enhancing lesion (and no-ICRs). ICRs were associated not only with neuropsychological performance decline but also with an increase in the daily cognitive difficulties. These findings support the ecological relevance of ICRs.

AB - Isolated cognitive relapses (ICRs) are transient deficits in cognitive performance that are the only presentation of a multiple sclerosis (MS) relapse. Here, we evaluated the impact of ICRs on cognitive difficulties in daily activities (assessed with the Multiple Sclerosis Neuropsychological Screening Questionnaire, Informant Version (MSNQ-I)) to characterize ICRs’ clinical relevance. We used 2-year-long retrospective data to compare 15 relapsing-remitting MS (RRMS) patients with ICRs with 57 RRMS patients presenting an asymptomatic gadolinium enhancing lesion (and no-ICRs). ICRs were associated not only with neuropsychological performance decline but also with an increase in the daily cognitive difficulties. These findings support the ecological relevance of ICRs.

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KW - quality of life

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Ecological impact of isolated cognitive relapses in MS

Abstract

Keywords

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