Echocardiographic Quantification of Superior Vena Cava (SVC) Flow in Neonates: Pilot Study of Modified Technique

Benjamim Ficial, Iuri Corsini, Elena Bonafiglia, Enrico Petoello, Alice Iride Flore, Silvia Nogara, Nicola Tsatsaris, Alan M. Groves

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Ultrasound Superior Vena Cava (SVC) flow assessment is a common measure of systemic and cerebral perfusion, although accuracy is limited. The aim of this study was to evaluate whether any improvements in accuracy could be achieved by measuring stroke distance from the instantaneous mean velocity, rather than from peak velocity, and by directly tracing area from images obtained with a high frequency linear probe. Paired phase contrast magnetic resonance imaging (PCMRI) and ultrasound assessments of SVC flow were performed in a pilot cohort of 7 infants. Median postnatal age, corrected gestation and weight at scan were 7 (2–74) days, 34.8 (31.7–37.2) weeks 1870 (970–2660) g. Median interval between PCMRI and ultrasound scans was 0.3 (0.2–0.5) h. The methodology trialed here showed a better agreement with PCMRI (mean bias −8 mL/kg/min, LOA −25–+8 mL/kg/min), compared to both the original method reported by Kluckow et al. (mean bias + 42 mL/kg/min, LOA −53–+137 mL/kg/min), and our own prior adaptation (mean bias + 23 mL/kg/min, LOA −25–+71 mL/kg/min). Ultrasound assessment of SVC flow volume using the modifications described led to enhanced accuracy and decreased variability compared to prior techniques in a small cohort of premature infants.

Original languageEnglish
Article number2083
Issue number9
StatePublished - Sep 2022
Externally publishedYes


  • MRI
  • Phase-contrast MRI
  • SVC flow
  • cerebral blood flow
  • doppler
  • echocardiography
  • neonate
  • perfusion
  • preterm
  • systemic blood flow


Dive into the research topics of 'Echocardiographic Quantification of Superior Vena Cava (SVC) Flow in Neonates: Pilot Study of Modified Technique'. Together they form a unique fingerprint.

Cite this