Echocardiographic Left Ventricular Mass Estimation: Two-Dimensional Area-Length Method is Superior to M-Mode Linear Method in Swine Models of Cardiac Diseases

Satoshi Miyashita, Nadjib Hammoudi, Shin Watanabe, Olympia Bikou, Kelly Yamada, Jaume Aguero, Koichi Nomoto, Taro Kariya, Kenneth Fish, Roger J. Hajjar, Kiyotake Ishikawa

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Echocardiography offers rapid and cost-effective estimations of left ventricular (LV) mass, but its accuracy in patients with cardiac disease remains unclear. LV mass was measured by M-mode-based linear method and two-dimensional echocardiography (2DE)-based area-length method in pig models and correlation with actual LV weight was assessed. Twenty-six normal, 195 ischemic heart disease (IHD), and 33 non-IHD HF pigs were included. A strong positive linear relationship to the actual LV weight was found with 2DE-based area-length method (r = 0.82, p < 0.001), whereas a moderate relationship was found with M-mode method in the overall population (r = 0.68, p < 0.001). Two correlation coefficients were significantly different (p < 0.001), and were driven mainly by incremental overestimation of LV mass in heavier hearts using the M-mode method. IHD and LV dilation were the factors contributing to overestimation using M-mode method. 2DE-based area-length method provides a better estimation of LV weight in swine models of HF, particularly in those with IHD.

Original languageEnglish
Pages (from-to)648-658
Number of pages11
JournalJournal of Cardiovascular Translational Research
Volume13
Issue number4
DOIs
StatePublished - 1 Aug 2020

Keywords

  • Cardiac disease
  • Dilation
  • Echocardiography
  • Heart mass
  • Hypertrophy
  • Infarction
  • Scar

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