Echinacea purpurea aerial extract alters course of influenza infection in mice

Dahlene Fusco, Xinyan Liu, Caroline Savage, Ying Taur, Weilie Xiao, Edward Kennelly, Jianda Yuan, Barrie Cassileth, Mirella Salvatore, Genovefa A. Papanicolaou

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Influenza infection is a major clinical problem and Echinacea purpurea, a widely consumed botanical product, is purported to alter the course of respiratory infections including influenza. Mice infected with WSN influenza A and treated with E. purpurea polysaccharide extract had less weight loss than untreated mice but similar pulmonary viral titers. Echinacea-treated mice had lower systemic and pulmonary KC and IL-10 levels and lower systemic IFN-γ levels following influenza infection. These suggest that E. purpurea alters the clinical course of influenza infection in mice through modulation of cytokines and not direct antiviral activity.

Original languageEnglish
Pages (from-to)3956-3962
Number of pages7
JournalVaccine
Volume28
Issue number23
DOIs
StatePublished - 21 May 2010
Externally publishedYes

Keywords

  • Cytokines
  • Echinacea
  • Influenza
  • Mice

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