Ebola virus persistence as a new focus in clinical research

Katie Caviness, Jens H. Kuhn, Gustavo Palacios

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Ebola virus (EBOV) causes severe acute human disease with high lethality. Viremia is typical during the acute disease phase. However, EBOV RNA can remain detectable in immune-privileged tissues for prolonged periods of time after clearance from the blood, suggesting EBOV may persist during convalescence and thereafter. Eliminating persistent EBOV is important to ensure full recovery of survivors and decrease the risk of outbreak re-ignition caused by EBOV spread from apparently healthy survivors to naive contacts. Here, we review prior evidence of EBOV persistence and explore the tools needed for the development of model systems to understand persistence.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalCurrent Opinion in Virology
Volume23
DOIs
StatePublished - 1 Apr 2017
Externally publishedYes

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