Early Stages of Automated Insulin Delivery

Howard Zisser; Roman Hovorka; Ananda Basu; Tadej Battelino; Charlotte K. Boughton; Marc D. Breton; Bruce A. Buckingham; Sue A. Brown; Daniel R. Cherñavvsky; Eyal Dassau; Mark D. DeBoer; Francis J. Doyle; Laya Ekhlaspour; Chiara Fabris; Gregory P. Forlenza; Ahmad Haidar; David C. Klonoff; Boris Kovatchev; Aaron J. Kowalski; Carol J. Levy; Yogish C. Kudva; David M. Maahs; Moshe Phillip; Eric Renard; Steven J. Russell; Viral N. Shah; Garry M. Steil; R. Paul Wadwa; Stuart A. Weinzimer

doi:10.1177/19322968251335685

Early Stages of Automated Insulin Delivery

Howard Zisser
, Roman Hovorka
, Ananda Basu
, Tadej Battelino
, Charlotte K. Boughton
, Marc D. Breton
, Bruce A. Buckingham
, Sue A. Brown
, Daniel R. Cherñavvsky
, Eyal Dassau
, Mark D. DeBoer
, Francis J. Doyle
, Laya Ekhlaspour
, Chiara Fabris
, Gregory P. Forlenza
, Ahmad Haidar
, David C. Klonoff
, Boris Kovatchev
, Aaron J. Kowalski
, Carol J. Levy

Yogish C. Kudva, David M. Maahs, Moshe Phillip, Eric Renard, Steven J. Russell, Viral N. Shah, Garry M. Steil, R. Paul Wadwa, Stuart A. Weinzimer

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The development of automated insulin delivery systems has seen tremendous improvements from individual components to interoperable system combinations of devices and new drugs besides insulin. The components have become progressively smaller, more accurate, and more user friendly. This article summarizes the history of the artificial pancreas from the earliest concepts to fully functional systems to research into further improvements in the future. The authors include many of the developers of this technology who received research support from the National Institute of Diabetes and Digestive and Kidney Diseases at various stages to develop these systems.

Original language	English
Pages (from-to)	908-923
Number of pages	16
Journal	Journal of diabetes science and technology
Volume	19
Issue number	4
DOIs	https://doi.org/10.1177/19322968251335685
State	Published - Jul 2025

Keywords

AID
NIDDK
artificial pancreas
automated insulin delivery

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10.1177/19322968251335685

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Zisser, H., Hovorka, R., Basu, A., Battelino, T., Boughton, C. K., Breton, M. D., Buckingham, B. A., Brown, S. A., Cherñavvsky, D. R., Dassau, E., DeBoer, M. D., Doyle, F. J., Ekhlaspour, L., Fabris, C., Forlenza, G. P., Haidar, A., Klonoff, D. C., Kovatchev, B., Kowalski, A. J., ... Weinzimer, S. A. (2025). Early Stages of Automated Insulin Delivery. Journal of diabetes science and technology, 19(4), 908-923. https://doi.org/10.1177/19322968251335685

@article{d80c29a5590b4d26bc4aa0c972c158e9,

title = "Early Stages of Automated Insulin Delivery",

abstract = "The development of automated insulin delivery systems has seen tremendous improvements from individual components to interoperable system combinations of devices and new drugs besides insulin. The components have become progressively smaller, more accurate, and more user friendly. This article summarizes the history of the artificial pancreas from the earliest concepts to fully functional systems to research into further improvements in the future. The authors include many of the developers of this technology who received research support from the National Institute of Diabetes and Digestive and Kidney Diseases at various stages to develop these systems.",

keywords = "AID, NIDDK, artificial pancreas, automated insulin delivery",

author = "Howard Zisser and Roman Hovorka and Ananda Basu and Tadej Battelino and Boughton, \{Charlotte K.\} and Breton, \{Marc D.\} and Buckingham, \{Bruce A.\} and Brown, \{Sue A.\} and Cher{\~n}avvsky, \{Daniel R.\} and Eyal Dassau and DeBoer, \{Mark D.\} and Doyle, \{Francis J.\} and Laya Ekhlaspour and Chiara Fabris and Forlenza, \{Gregory P.\} and Ahmad Haidar and Klonoff, \{David C.\} and Boris Kovatchev and Kowalski, \{Aaron J.\} and Levy, \{Carol J.\} and Kudva, \{Yogish C.\} and Maahs, \{David M.\} and Moshe Phillip and Eric Renard and Russell, \{Steven J.\} and Shah, \{Viral N.\} and Steil, \{Garry M.\} and Wadwa, \{R. Paul\} and Weinzimer, \{Stuart A.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).",

year = "2025",

month = jul,

doi = "10.1177/19322968251335685",

language = "English",

volume = "19",

pages = "908--923",

journal = "Journal of diabetes science and technology",

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Zisser, H, Hovorka, R, Basu, A, Battelino, T, Boughton, CK, Breton, MD, Buckingham, BA, Brown, SA, Cherñavvsky, DR, Dassau, E, DeBoer, MD, Doyle, FJ, Ekhlaspour, L, Fabris, C, Forlenza, GP, Haidar, A, Klonoff, DC, Kovatchev, B, Kowalski, AJ, Levy, CJ, Kudva, YC, Maahs, DM, Phillip, M, Renard, E, Russell, SJ, Shah, VN, Steil, GM, Wadwa, RP & Weinzimer, SA 2025, 'Early Stages of Automated Insulin Delivery', Journal of diabetes science and technology, vol. 19, no. 4, pp. 908-923. https://doi.org/10.1177/19322968251335685

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AU - Hovorka, Roman

AU - Basu, Ananda

AU - Battelino, Tadej

AU - Boughton, Charlotte K.

AU - Breton, Marc D.

AU - Buckingham, Bruce A.

AU - Brown, Sue A.

AU - Cherñavvsky, Daniel R.

AU - Dassau, Eyal

AU - DeBoer, Mark D.

AU - Doyle, Francis J.

AU - Ekhlaspour, Laya

AU - Fabris, Chiara

AU - Forlenza, Gregory P.

AU - Haidar, Ahmad

AU - Klonoff, David C.

AU - Kovatchev, Boris

AU - Kowalski, Aaron J.

AU - Levy, Carol J.

AU - Kudva, Yogish C.

AU - Maahs, David M.

AU - Phillip, Moshe

AU - Renard, Eric

AU - Russell, Steven J.

AU - Shah, Viral N.

AU - Steil, Garry M.

AU - Wadwa, R. Paul

AU - Weinzimer, Stuart A.

N1 - Publisher Copyright: © The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PY - 2025/7

Y1 - 2025/7

N2 - The development of automated insulin delivery systems has seen tremendous improvements from individual components to interoperable system combinations of devices and new drugs besides insulin. The components have become progressively smaller, more accurate, and more user friendly. This article summarizes the history of the artificial pancreas from the earliest concepts to fully functional systems to research into further improvements in the future. The authors include many of the developers of this technology who received research support from the National Institute of Diabetes and Digestive and Kidney Diseases at various stages to develop these systems.

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KW - AID

KW - NIDDK

KW - artificial pancreas

KW - automated insulin delivery

UR - https://www.scopus.com/pages/publications/105010288219

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DO - 10.1177/19322968251335685

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SP - 908

EP - 923

JO - Journal of diabetes science and technology

JF - Journal of diabetes science and technology

IS - 4

ER -

Early Stages of Automated Insulin Delivery

Abstract

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