Early Real-World Physician Experience with an Intracanalicular Dexamethasone Insert

Cynthia Matossian, John D. Stephens, Michelle K. Rhee, Stephen E. Smith, Parag A. Majmudar, Subba Rao Gollamudi, Ravi H. Patel, Maria E. Rosselson, Aditi Bauskar, Alyssa Montieth, Fabiana Q. Silva, Srilatha Vantipalli, Andrea Gibson, Jamie Lynne Metzinger, Michael H. Goldstein

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: To describe the early real-world experience of physicians with an intracanalicular dexamethasone insert (DEX) in patients undergoing cataract surgery and to capture the clinical impact of adopting this therapy. Patients and Methods: 23 United States sites including Ambulatory Surgical Center Setting (ASC) and Outpatient Clinical settings. Respondents were physicians who had early experience with DEX in cataract surgery patients. This was a Phase 4 experiential cross-sectional survey study comprised of 3 sequential online physician surveys. Descriptive statistics summarized the surveys’ responses to determine the early impressions of the respondents. Results: Forty-two physicians completed surveys. On average, physicians reported feeling comfortable administering DEX after placing 3 inserts (mean 2.7; standard deviation 1.9). Most physicians (92%) were satisfied with DEX, and all physicians (100%) reported that DEX improved patient compliance. Most physicians (62.5%) indicated they would highly prefer DEX over traditional steroid eyedrops for the management of post-surgical inflammation and pain. Conclusion: The surveys exploring the early use of DEX suggest that DEX is a clinically effective treatment with a rapid initial learning curve and integrates well into clinical use. Physicians had a very positive early experience with DEX, including comfort with insertion and satisfaction. DEX shows promise as a primary treatment choice of physicians for ocular inflammation and pain following cataract surgery by offering patients a hands-free innovative therapy that delivers a preservative-free steroid to the ocular surface over approximately 30 days.

Original languageEnglish
Pages (from-to)2429-2440
Number of pages12
JournalClinical Ophthalmology
Volume16
DOIs
StatePublished - 2022

Keywords

  • hands-free therapy
  • intracanalicular dexamethasone insert
  • ocular inflammation
  • ocular pain
  • phacoemulsification
  • sustained-release drug delivery

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