TY - JOUR
T1 - Early life stress alters transcriptomic patterning across reward circuitry in male and female mice
AU - Peña, Catherine Jensen
AU - Smith, Milo
AU - Ramakrishnan, Aarthi
AU - Cates, Hannah M.
AU - Bagot, Rosemary C.
AU - Kronman, Hope G.
AU - Patel, Bhakti
AU - Chang, Austin B.
AU - Purushothaman, Immanuel
AU - Dudley, Joel
AU - Morishita, Hirofumi
AU - Shen, Li
AU - Nestler, Eric J.
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychiatric disorders including depression. In this study, we show that ELS in a postnatal sensitive period increases sensitivity to adult stress in female mice, consistent with our earlier findings in male mice. We used RNA-sequencing in the ventral tegmental area, nucleus accumbens, and prefrontal cortex of male and female mice to show that adult stress is distinctly represented in the brain’s transcriptome depending on ELS history. We identify: 1) biological pathways disrupted after ELS and associated with increased behavioral stress sensitivity, 2) putative transcriptional regulators of the effect of ELS on adult stress response, and 3) subsets of primed genes specifically associated with latent behavioral changes. We also provide transcriptomic evidence that ELS increases sensitivity to future stress through enhancement of known programs of cortical plasticity.
AB - Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychiatric disorders including depression. In this study, we show that ELS in a postnatal sensitive period increases sensitivity to adult stress in female mice, consistent with our earlier findings in male mice. We used RNA-sequencing in the ventral tegmental area, nucleus accumbens, and prefrontal cortex of male and female mice to show that adult stress is distinctly represented in the brain’s transcriptome depending on ELS history. We identify: 1) biological pathways disrupted after ELS and associated with increased behavioral stress sensitivity, 2) putative transcriptional regulators of the effect of ELS on adult stress response, and 3) subsets of primed genes specifically associated with latent behavioral changes. We also provide transcriptomic evidence that ELS increases sensitivity to future stress through enhancement of known programs of cortical plasticity.
UR - http://www.scopus.com/inward/record.url?scp=85074711408&partnerID=8YFLogxK
U2 - 10.1038/s41467-019-13085-6
DO - 10.1038/s41467-019-13085-6
M3 - Article
C2 - 31704941
AN - SCOPUS:85074711408
SN - 2041-1723
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5098
ER -