Early hepatocellular carcinoma: Pathology, imaging, and therapy

Tadatoshi Takayama, Masatoshi Makuuchi, Masamichi Kojiro, Gregory Y. Lauwers, Reid B. Adams, Stephanie R. Wilson, Hyun Jung Jang, Chusilp Charnsangavej, Bachir Taouli

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Background: In 1987, Japanese researchers proposed to define the pathological concept of early hepatocellular carcinoma (HCC). However, there are some conceptual differences between the East and the West in the diagnosis and treatment of early HCC. Methods: To provide up-to-date data for making a worldwide consensus, this article has collected six papers focused on the management of early HCC, which were presented in the Fifth International Meeting of "Hepatocellular Carcinoma: Eastern and Western Experiences" in Houston in January 2007. Results: In the pathological perspective, the common criteria to discriminate early HCC from dysplastic nodule included hepatocytic invasion of portal triads and septa (stromal invasion). The current imaging modalities such as contrast-enhanced ultrasound (CEUS), computed tomography (CT), and magnetic resonance imaging (MRI) with the use of intravenous contrast material with multiphasic imaging could enhance their ability to accurately characterize early HCC. From the treatment perspective, a single early HCC had a high chance for cure by resection, ablation, or transplantation, which proved to be the earliest clinical entity (Stage 0 HCC). Conclusions: Early HCC is characterized by its incipient malignant nature and by an extremely favorable clinical outcome, thereby justifying its definition.

Original languageEnglish
Pages (from-to)972-978
Number of pages7
JournalAnnals of Surgical Oncology
Issue number4
StatePublished - Apr 2008
Externally publishedYes


  • Early HCC
  • Hepatocellular carcinoma
  • Imaging
  • Pathology
  • Therapy


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