Early detection of recurrent HPV+ hypopharyngeal squamous cell carcinoma by circulating tumor DNA

Derek D. Kao; Marshall R. Posner; Scott A. Roof

doi:10.1016/j.xocr.2023.100537

Early detection of recurrent HPV+ hypopharyngeal squamous cell carcinoma by circulating tumor DNA

Derek D. Kao, Marshall R. Posner, Scott A. Roof

Research output: Contribution to journal › Article › peer-review

Abstract

Circulating tumor DNA is a liquid biomarker that offers a highly specific method to assess HPV-associated tumor burden via a blood draw. It has the potential for many clinical applications in cancer care, including prognostication, monitoring treatment response, and surveillance for disease recurrence. In this case report, we present a case of recurrent HPV-associated hypopharyngeal squamous cell carcinoma first detected by circulating tumor HPV DNA that demonstrates the role of circulating tumor HPV DNA tests in posttreatment surveillance and the utility of HPV testing in all HPV-mediated tumors, regardless of subsite.

Original language	English
Article number	100537
Journal	Otolaryngology Case Reports
Volume	27
DOIs	https://doi.org/10.1016/j.xocr.2023.100537
State	Published - Jun 2023

Keywords

Circulating tumor DNA
Head and neck cancer
Human papillomavirus

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10.1016/j.xocr.2023.100537

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title = "Early detection of recurrent HPV+ hypopharyngeal squamous cell carcinoma by circulating tumor DNA",

abstract = "Circulating tumor DNA is a liquid biomarker that offers a highly specific method to assess HPV-associated tumor burden via a blood draw. It has the potential for many clinical applications in cancer care, including prognostication, monitoring treatment response, and surveillance for disease recurrence. In this case report, we present a case of recurrent HPV-associated hypopharyngeal squamous cell carcinoma first detected by circulating tumor HPV DNA that demonstrates the role of circulating tumor HPV DNA tests in posttreatment surveillance and the utility of HPV testing in all HPV-mediated tumors, regardless of subsite.",

keywords = "Circulating tumor DNA, Head and neck cancer, Human papillomavirus",

author = "Kao, {Derek D.} and Posner, {Marshall R.} and Roof, {Scott A.}",

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AU - Posner, Marshall R.

AU - Roof, Scott A.

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AB - Circulating tumor DNA is a liquid biomarker that offers a highly specific method to assess HPV-associated tumor burden via a blood draw. It has the potential for many clinical applications in cancer care, including prognostication, monitoring treatment response, and surveillance for disease recurrence. In this case report, we present a case of recurrent HPV-associated hypopharyngeal squamous cell carcinoma first detected by circulating tumor HPV DNA that demonstrates the role of circulating tumor HPV DNA tests in posttreatment surveillance and the utility of HPV testing in all HPV-mediated tumors, regardless of subsite.

KW - Circulating tumor DNA

KW - Head and neck cancer

KW - Human papillomavirus

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ER -

Early detection of recurrent HPV+ hypopharyngeal squamous cell carcinoma by circulating tumor DNA

Abstract

Keywords

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