Early de-escalation of empiric antibiotic therapy in neutropenic fever: a single-center, retrospective study

Zachary Mostel; Michelle Evans; Douglas Tremblay; Meenakshi Rana; Samantha E. Jacobs; John Mascarenhas; Alla Keyzner; Daniel Park; Risa Fuller

doi:10.1017/ash.2025.10208

Early de-escalation of empiric antibiotic therapy in neutropenic fever: a single-center, retrospective study

Zachary Mostel
, Michelle Evans
, Douglas Tremblay
, Meenakshi Rana
, Samantha E. Jacobs
, John Mascarenhas
, Alla Keyzner
, Daniel Park
, Risa Fuller

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We implemented a policy to discontinue empiric antibiotics after 48 hours of defervescence in neutropenic fever with no identified clinical/microbiologic infection. Among patients with acute myeloid leukemia or hematopoietic stem cell transplant, early de-escalation was not associated with increased subsequent infection, decompensation, or mortality, supporting its safety and feasibility.

Original language	English
Article number	e292
Journal	Antimicrobial Stewardship and Healthcare Epidemiology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1017/ash.2025.10208
State	Published - 30 Oct 2025

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abstract = "We implemented a policy to discontinue empiric antibiotics after 48 hours of defervescence in neutropenic fever with no identified clinical/microbiologic infection. Among patients with acute myeloid leukemia or hematopoietic stem cell transplant, early de-escalation was not associated with increased subsequent infection, decompensation, or mortality, supporting its safety and feasibility.",

author = "Zachary Mostel and Michelle Evans and Douglas Tremblay and Meenakshi Rana and Jacobs, \{Samantha E.\} and John Mascarenhas and Alla Keyzner and Daniel Park and Risa Fuller",

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AU - Tremblay, Douglas

AU - Rana, Meenakshi

AU - Jacobs, Samantha E.

AU - Mascarenhas, John

AU - Keyzner, Alla

AU - Park, Daniel

AU - Fuller, Risa

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AB - We implemented a policy to discontinue empiric antibiotics after 48 hours of defervescence in neutropenic fever with no identified clinical/microbiologic infection. Among patients with acute myeloid leukemia or hematopoietic stem cell transplant, early de-escalation was not associated with increased subsequent infection, decompensation, or mortality, supporting its safety and feasibility.

UR - https://www.scopus.com/pages/publications/105024139435

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JO - Antimicrobial Stewardship and Healthcare Epidemiology

JF - Antimicrobial Stewardship and Healthcare Epidemiology

IS - 1

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ER -

Early de-escalation of empiric antibiotic therapy in neutropenic fever: a single-center, retrospective study

Abstract

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