TY - JOUR
T1 - Early de-escalation of empiric antibiotic therapy in neutropenic fever
T2 - a single-center, retrospective study
AU - Mostel, Zachary
AU - Evans, Michelle
AU - Tremblay, Douglas
AU - Rana, Meenakshi
AU - Jacobs, Samantha E.
AU - Mascarenhas, John
AU - Keyzner, Alla
AU - Park, Daniel
AU - Fuller, Risa
N1 - Publisher Copyright:
© The Author(s), 2025. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America.
PY - 2025/10/30
Y1 - 2025/10/30
N2 - We implemented a policy to discontinue empiric antibiotics after 48 hours of defervescence in neutropenic fever with no identified clinical/microbiologic infection. Among patients with acute myeloid leukemia or hematopoietic stem cell transplant, early de-escalation was not associated with increased subsequent infection, decompensation, or mortality, supporting its safety and feasibility.
AB - We implemented a policy to discontinue empiric antibiotics after 48 hours of defervescence in neutropenic fever with no identified clinical/microbiologic infection. Among patients with acute myeloid leukemia or hematopoietic stem cell transplant, early de-escalation was not associated with increased subsequent infection, decompensation, or mortality, supporting its safety and feasibility.
UR - https://www.scopus.com/pages/publications/105024139435
U2 - 10.1017/ash.2025.10208
DO - 10.1017/ash.2025.10208
M3 - Article
AN - SCOPUS:105024139435
SN - 2732-494X
VL - 5
JO - Antimicrobial Stewardship and Healthcare Epidemiology
JF - Antimicrobial Stewardship and Healthcare Epidemiology
IS - 1
M1 - e292
ER -