Dysregulation of anti-tumor immunity by the matrix metalloproteinase-2

Emmanuelle Godefroy; Nina Bhardwaj

doi:10.4161/onci.1.1.17994

Dysregulation of anti-tumor immunity by the matrix metalloproteinase-2

Emmanuelle Godefroy
, Nina Bhardwaj

Research output: Contribution to journal › Comment/debate

9 Scopus citations

Abstract

The matrix metalloproteinase-2 (MMP-2), over-expressed in most cancers, induces T_H2 polarization by conditioning dendritic cells to over-express OX40L and down-regulate IL-12p70 through the degradation of the type-I IFN receptor IFNAR1. Elucidating mechanisms underlying detrimental tumor-associated type-2 responses represent a crucial step in designing effective immune therapies to treat cancer patients.

Original language	English
Pages (from-to)	109-111
Number of pages	3
Journal	OncoImmunology
Volume	1
Issue number	1
DOIs	https://doi.org/10.4161/onci.1.1.17994
State	Published - 2012
Externally published	Yes

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title = "Dysregulation of anti-tumor immunity by the matrix metalloproteinase-2",

abstract = "The matrix metalloproteinase-2 (MMP-2), over-expressed in most cancers, induces TH2 polarization by conditioning dendritic cells to over-express OX40L and down-regulate IL-12p70 through the degradation of the type-I IFN receptor IFNAR1. Elucidating mechanisms underlying detrimental tumor-associated type-2 responses represent a crucial step in designing effective immune therapies to treat cancer patients.",

author = "Emmanuelle Godefroy and Nina Bhardwaj",

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T1 - Dysregulation of anti-tumor immunity by the matrix metalloproteinase-2

AU - Godefroy, Emmanuelle

AU - Bhardwaj, Nina

PY - 2012

Y1 - 2012

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AB - The matrix metalloproteinase-2 (MMP-2), over-expressed in most cancers, induces TH2 polarization by conditioning dendritic cells to over-express OX40L and down-regulate IL-12p70 through the degradation of the type-I IFN receptor IFNAR1. Elucidating mechanisms underlying detrimental tumor-associated type-2 responses represent a crucial step in designing effective immune therapies to treat cancer patients.

UR - https://www.scopus.com/pages/publications/84886945232

U2 - 10.4161/onci.1.1.17994

DO - 10.4161/onci.1.1.17994

M3 - Comment/debate

AN - SCOPUS:84886945232

SN - 2162-4011

VL - 1

SP - 109

EP - 111

JO - OncoImmunology

JF - OncoImmunology

IS - 1

ER -

Dysregulation of anti-tumor immunity by the matrix metalloproteinase-2

Abstract

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