Abstract
The matrix metalloproteinase-2 (MMP-2), over-expressed in most cancers, induces TH2 polarization by conditioning dendritic cells to over-express OX40L and down-regulate IL-12p70 through the degradation of the type-I IFN receptor IFNAR1. Elucidating mechanisms underlying detrimental tumor-associated type-2 responses represent a crucial step in designing effective immune therapies to treat cancer patients.
| Original language | English |
|---|---|
| Pages (from-to) | 109-111 |
| Number of pages | 3 |
| Journal | OncoImmunology |
| Volume | 1 |
| Issue number | 1 |
| DOIs |
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| State | Published - 2012 |
| Externally published | Yes |