Dysregulation of anti-tumor immunity by the matrix metalloproteinase-2

Emmanuelle Godefroy, Nina Bhardwaj

Research output: Contribution to journalComment/debate

6 Scopus citations


The matrix metalloproteinase-2 (MMP-2), over-expressed in most cancers, induces TH2 polarization by conditioning dendritic cells to over-express OX40L and down-regulate IL-12p70 through the degradation of the type-I IFN receptor IFNAR1. Elucidating mechanisms underlying detrimental tumor-associated type-2 responses represent a crucial step in designing effective immune therapies to treat cancer patients.

Original languageEnglish
Pages (from-to)109-111
Number of pages3
Issue number1
StatePublished - 2012
Externally publishedYes


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