@article{6b720a9328a346c099ace18cd8107527,
title = "Dysregulated Epstein-Barr virus infection in patients with CIDP",
abstract = "Ubiquitous viruses have frequently been proposed as a cause or trigger of chronic immune-mediated diseases. Infections are reported to be temporally associated with clinical exacerbations in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We examined immunological parameters of herpesvirus infections in untreated patients with CIDP compared to demographically matched controls. Patients with CIDP were uniformly seropositive for EBV-specific IgG and the disease was associated with a moderately enhanced IgG reactivity to EBV-encoded antigens expressed during both B cell transformation and productive viral replication. Moreover, cellular EBV copy numbers were 3-fold increased in patients with CIDP. In contrast, humoral immune responses to other herpesviruses (HCMV, HSV) as well as virus-specific IgM responses were unchanged in CIDP. These data indicate that host-pathogen interactions during chronic EBV infection are dysregulated in treatment-na{\"i}ve patients with CIDP.",
keywords = "Autoimmunity, CIDP, EBV, Herpesvirus, Infection",
author = "L{\"u}nemann, \{J. D.\} and B. Tackenberg and A. Stein and Wandinger, \{K. P.\} and Oertel, \{W. H.\} and Wagner, \{H. J.\} and C. M{\"u}nz and H. Meisel and N. Sommer and F. Zipp",
note = "Funding Information: J.D.L. is a recipient of the Dana Foundation and Irvington Institute's Human Immunology Fellowship and is supported by an Institutional Clinical and Translational Science Pilot and Collaborative Project Grant (to the Rockefeller University Hospital) and the Gemeinn{\"u}tzige Hertie-Stiftung . B.T. is supported by the F{\"o}rderverein Neurologie e . V. C.M. is supported by the Arnold and Mabel Beckman Foundation , the Alexandrine and Alexander Sinsheimer Foundation , the Burroughs Wellcome Fund , the Dana Foundation's Neuroimmunology program , the National Cancer Institute ( R01CA108609 and R01CA101741 ), the National Institute of Allergy and Infectious diseases ( RFP-NIH-NIAID-DAIDS-BAA-06-19 ), the Foundation for the National Institutes of Health (Grand Challenges in Global Health) , and an Institutional Clinical and Translational Science Award (to the Rockefeller University Hospital). This work was supported by the German Federal Ministry of Education and Research ( BMBF-NBL III , to F.Z.). ",
year = "2010",
month = jan,
day = "25",
doi = "10.1016/j.jneuroim.2009.11.003",
language = "English",
volume = "218",
pages = "107--111",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier B.V.",
number = "1-2",
}