Dynamics of Splenic Transient Elastography in Patients with Alcohol Use Disorder

Mian B. Khalid; Hanna L. Blaney; Anusha Vittal; Alexander H. Yang; Bilal A. Asif; Natasha Kamal; Elizabeth C. Wright; Chris Koh; David George; David Goldman; Yvonne Horneffer; Nancy Diazgranados; Theo Heller

doi:10.14309/ctg.0000000000000770

Dynamics of Splenic Transient Elastography in Patients with Alcohol Use Disorder

Mian B. Khalid
, Hanna L. Blaney
, Anusha Vittal
, Alexander H. Yang
, Bilal A. Asif
, Natasha Kamal
, Elizabeth C. Wright
, Chris Koh
, David George
, David Goldman
, Yvonne Horneffer
, Nancy Diazgranados
, Theo Heller

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION:Splenic stiffness (SS) measurement (SSM) is an evolving noninvasive assessment to evaluate portal hypertension. Studies with respect to SSM in patients with alcohol use disorder are limited.METHODS:We studied patients seeking treatment for alcohol use disorder in an inpatient treatment protocol at the National Institutes of Health and parsed SSM into 3 groups based on degree of change.RESULTS:The improved SS group had statistically higher initial SSM and a nonstatistically increased liver stiffness measurement compared with others.DISCUSSION:SS is dynamic in a subset of patients immediately after alcohol cessation, and improved SS is associated with a normalization of platelet count.

Original language	English
Pages (from-to)	e00770
Journal	Clinical and Translational Gastroenterology
Volume	15
Issue number	11
DOIs	https://doi.org/10.14309/ctg.0000000000000770
State	Published - 23 Sep 2024
Externally published	Yes

Keywords

alcohol
alcohol use disorder
liver stiffness
noninvasive liver disease assessment
splenic stiffness

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10.14309/ctg.0000000000000770

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Khalid, M. B., Blaney, H. L., Vittal, A., Yang, A. H., Asif, B. A., Kamal, N., Wright, E. C., Koh, C., George, D., Goldman, D., Horneffer, Y., Diazgranados, N., & Heller, T. (2024). Dynamics of Splenic Transient Elastography in Patients with Alcohol Use Disorder. Clinical and Translational Gastroenterology, 15(11), e00770. https://doi.org/10.14309/ctg.0000000000000770

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title = "Dynamics of Splenic Transient Elastography in Patients with Alcohol Use Disorder",

abstract = "INTRODUCTION:Splenic stiffness (SS) measurement (SSM) is an evolving noninvasive assessment to evaluate portal hypertension. Studies with respect to SSM in patients with alcohol use disorder are limited.METHODS:We studied patients seeking treatment for alcohol use disorder in an inpatient treatment protocol at the National Institutes of Health and parsed SSM into 3 groups based on degree of change.RESULTS:The improved SS group had statistically higher initial SSM and a nonstatistically increased liver stiffness measurement compared with others.DISCUSSION:SS is dynamic in a subset of patients immediately after alcohol cessation, and improved SS is associated with a normalization of platelet count.",

keywords = "alcohol, alcohol use disorder, liver stiffness, noninvasive liver disease assessment, splenic stiffness",

author = "Khalid, \{Mian B.\} and Blaney, \{Hanna L.\} and Anusha Vittal and Yang, \{Alexander H.\} and Asif, \{Bilal A.\} and Natasha Kamal and Wright, \{Elizabeth C.\} and Chris Koh and David George and David Goldman and Yvonne Horneffer and Nancy Diazgranados and Theo Heller",

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year = "2024",

month = sep,

day = "23",

doi = "10.14309/ctg.0000000000000770",

language = "English",

volume = "15",

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TY - JOUR

T1 - Dynamics of Splenic Transient Elastography in Patients with Alcohol Use Disorder

AU - Khalid, Mian B.

AU - Blaney, Hanna L.

AU - Vittal, Anusha

AU - Yang, Alexander H.

AU - Asif, Bilal A.

AU - Kamal, Natasha

AU - Wright, Elizabeth C.

AU - Koh, Chris

AU - George, David

AU - Goldman, David

AU - Horneffer, Yvonne

AU - Diazgranados, Nancy

AU - Heller, Theo

PY - 2024/9/23

Y1 - 2024/9/23

N2 - INTRODUCTION:Splenic stiffness (SS) measurement (SSM) is an evolving noninvasive assessment to evaluate portal hypertension. Studies with respect to SSM in patients with alcohol use disorder are limited.METHODS:We studied patients seeking treatment for alcohol use disorder in an inpatient treatment protocol at the National Institutes of Health and parsed SSM into 3 groups based on degree of change.RESULTS:The improved SS group had statistically higher initial SSM and a nonstatistically increased liver stiffness measurement compared with others.DISCUSSION:SS is dynamic in a subset of patients immediately after alcohol cessation, and improved SS is associated with a normalization of platelet count.

AB - INTRODUCTION:Splenic stiffness (SS) measurement (SSM) is an evolving noninvasive assessment to evaluate portal hypertension. Studies with respect to SSM in patients with alcohol use disorder are limited.METHODS:We studied patients seeking treatment for alcohol use disorder in an inpatient treatment protocol at the National Institutes of Health and parsed SSM into 3 groups based on degree of change.RESULTS:The improved SS group had statistically higher initial SSM and a nonstatistically increased liver stiffness measurement compared with others.DISCUSSION:SS is dynamic in a subset of patients immediately after alcohol cessation, and improved SS is associated with a normalization of platelet count.

KW - alcohol

KW - alcohol use disorder

KW - liver stiffness

KW - noninvasive liver disease assessment

KW - splenic stiffness

UR - https://www.scopus.com/pages/publications/85205145880

U2 - 10.14309/ctg.0000000000000770

DO - 10.14309/ctg.0000000000000770

M3 - Article

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AN - SCOPUS:85205145880

SN - 2155-384X

VL - 15

SP - e00770

JO - Clinical and Translational Gastroenterology

JF - Clinical and Translational Gastroenterology

IS - 11

ER -

Dynamics of Splenic Transient Elastography in Patients with Alcohol Use Disorder

Abstract

Keywords

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